Artery Research

Volume 4, Issue 4, December 2010, Pages 148 - 148

5.3 ISOLATED SYSTOLIC HYPERTENSION DOES NOT RESULT FROM A SMALLER PROXIMAL AORTIC DIAMETER

Authors
S.S. Hickson1, *, E. Mousseaux2, M. Graves1, C.M. McEniery1, I.B. Wilkinson1
1University of Cambridge, Cambridge, United Kingdom
2The University of Paris-Descartes, Paris, France
*Corresponding author.
Corresponding Author
S.S. Hickson
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.174How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

It has been suggested that isolated systolic hypertension (ISH) may result from a smaller proximal aortic diameter. However, the available data are conflicting, no doubt because of different techniques and sites of measurement. We compared maximum (systolic) diameter, minimum (diastolic) diameter, and aortic distensibility at various levels along the thoracic aortic arch, between normotensive subjects (NT) and those with ISH, using MRI.

48 healthy subjects aged≥60 years, free of cardiovascular disease and medication were recruited from the ACCT Study. A Fiesta sequence (1.5T scanner,GE) was then performed in all subjects at 6 aortic levels: the aortic root (L1),1cm above the aortic valve (L2), proximal to the innominate artery (L3), distal to the left subclavian artery (L4), the descending aorta (L5) and the level of the diaphragm (L6). Diameters were determined using ARTFUN software.

Subject were divided into those with a normal blood pressure (<140/90 mmHg) and those with ISH (systolic≥140 mmHg, diastolic <90 mmHg), and were matched for age. Average systolic and diastolic aortic diameters were greater in subjects with ISH (Table 1). Distensibility was greater in normotensive subjects compared to those with ISH at L2-L6 (L1: 0.64±2.72 vs. 0.21±1.53; L2: 5.69±2.72 vs. 2.60±1.33; L3: 3.10±1.97 vs. 1.27±0.99; L4: 3.86±1.81 vs. 1.69±0.70; L5: 3.91±2.58 vs. 1.68±0.63; L6: 5.18±2.43 vs. 2.73±1.69, units=10−3 × mmHg−1, P<0.01 for L2-L6, P=0.5 for L1). With the exception of the aortic root, both systolic and diastolic proximal aortic diameters are greater in subjects with ISH compared to NT subjects, whereas distensibility is reduced.

Aortic Level Systolic Diameter (cm) NT Systolic Diameter (cm) ISH P Diastolic Diameter (cm) NT Diastolic Diameter (cm)ISH P
L1 3.09±0.41 3.18±0.28 0.317 3.05±0.41 3.18±0.24 0.331
L2 3.15±0.44 3.41±0.37 0.019* 3.03±0.45 3.33±0.36 0.012*
L3 3.06±0.34 3.27±0.33 0.038* 2.91±0.37 3.19±0.34 0.030*
L4 2.55±0.21 2.85±0.32 0.003* 2.39±0.22 2.74±0.31 <0*
L5 2.43±0.24 2.66±0.28 0.011* 2.30±0.24 2.56±0.27 0.004*
L6 2.34±0.24 2.44±0.25 0.112 2.15±0.23 2.30±0.22 0.044*
Journal
Artery Research
Volume-Issue
4 - 4
Pages
148 - 148
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.174How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - S.S. Hickson
AU  - E. Mousseaux
AU  - M. Graves
AU  - C.M. McEniery
AU  - I.B. Wilkinson
PY  - 2010
DA  - 2010/12/02
TI  - 5.3 ISOLATED SYSTOLIC HYPERTENSION DOES NOT RESULT FROM A SMALLER PROXIMAL AORTIC DIAMETER
JO  - Artery Research
SP  - 148
EP  - 148
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.174
DO  - 10.1016/j.artres.2010.10.174
ID  - Hickson2010
ER  -