Artery Research

Volume 4, Issue 4, December 2010, Pages 149 - 150

6.2 LARGE ARTERY STIFFNESS ASSESSMENT WITH ARTERIOGRAPH DEVICE

Authors
M. Alivon1, *, K.T. Ong1, H. Khettab1, S. Yanes1, J.F. Pruny1, E. Bozec1, J. Empana2, B. Pannier1, 3, S. Laurent1, H. Beaussier1, P. Boutouyrie1
1Hôpital Européen Georges Pompidou INSERM U970, Paris, France
2INSERM U970, Paris, France
3Institut prévention cardiovasculaire (IPC), Paris, France
*Corresponding author.
Corresponding Author
M. Alivon
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.179How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Large artery stiffness is recognized as a strong, independent marker of cardiovascular risk, mainly through aortic pulse wave velocity (PWV). Carotid stiffness (CS), directly measured from echo tracking is correlated with PWV and has been associated with CV risk. Arteriograph is a new non-invasive oscillometric method, which estimates aortic PWV through brachial pressure wave analysis and provides an aortic stiffness index (ASI).

Aim: To compare CS with echotracking to ASI with arteriograph and define their determinants and discrepancies in a large unselected middle age population.

Methods: CS was assessed by echotracking system (ArtLab®) and central pulse pressure by calibrated distension waveforms, ASI by Arteriograph. R-squared Pearson’s correlation coefficient (R2) between the methods was calculated.

Results: 682 patients were included: 68 healthy control subjects (CTL), 412 patients with “non treated risk factors” (NTRF) and 202 with “treated risk factors” (TRF). Among NTRF and CTL patients, correlation between CS and ASI were weak (R2=0.019 and 0.016 respectively, p<0.01). In a robust multiple stepwise regression analysis, ASI was determined by mean blood pressure (p-R2=0.066, p<0.001), independently of gender (p-R2=0.048, p<0.001) triglyceride (p-R2=0.044, p<0.001), whereas CS is associated with MBP (p-R2=0.093, p<0.001) and age (p-R2=0.043, p<0.001). CV drugs were associated with ASI (RAAS antagonists decreasing, calcium antagonists increasing), but not with CS.

Conclusion: ASI and CS are weakly correlated. Pressure and age, usually strong determinants of CS were modestly associated with ASI which appeared more sensitive to metabolic factors and drug treatments. Both techniques measure differently arterial stiffness and are not exchangeable.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
149 - 150
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.179How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M. Alivon
AU  - K.T. Ong
AU  - H. Khettab
AU  - S. Yanes
AU  - J.F. Pruny
AU  - E. Bozec
AU  - J. Empana
AU  - B. Pannier
AU  - S. Laurent
AU  - H. Beaussier
AU  - P. Boutouyrie
PY  - 2010
DA  - 2010/12/02
TI  - 6.2 LARGE ARTERY STIFFNESS ASSESSMENT WITH ARTERIOGRAPH DEVICE
JO  - Artery Research
SP  - 149
EP  - 150
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.179
DO  - 10.1016/j.artres.2010.10.179
ID  - Alivon2010
ER  -