PO-24 SEX DIFFERENCES IN HEMODYNAMIC RESPONSES FOLLOWING ACUTE INFLAMMATION: WAVE SEPARATION ANALYSIS

Sang Ouk Wee; Abbi Lane; Kanokwan Bunsawat; Alexander Rosenberg; Bo Fernhall

doi:10.1016/j.artres.2014.09.030

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Volume 8, Issue 4, December 2014, Pages 174 - 175

PO-24 SEX DIFFERENCES IN HEMODYNAMIC RESPONSES FOLLOWING ACUTE INFLAMMATION: WAVE SEPARATION ANALYSIS

Authors

Sang Ouk Wee^a, Abbi Lane^b, Kanokwan Bunsawat^a, Alexander Rosenberg^a, Bo Fernhall^a

^aUniversity of Illinois at Chicago, Chicago, IL, USA

^bUniversity of Iowa, IA, USA

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.030 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Acute inflammation temporarily increases risk of cardiovascular events and alters hemodynamics. However, it is unknown whether acute inflammation differentially affects blood pressure and pulse wave characteristics, including forward or reflected pressure waves, in males versus females.

Objectives: The purpose of this study was to investigate the potential sex differences in the response to acute inflammation in blood pressure and pulse wave characteristics, measured with wave separation analysis.

Methods: 63 adults (29 males, 34 females) participated in the study. Participants received an influenza vaccine to induce acute inflammation. Central blood pressure and pulse waves were measured using tonometry and separated into forward and reflected waves, at baseline, 24hr post, and 48 hr post-vaccination. 2 x 3 repeated measure Analysis of Variance (ANOVA) was performed to investigate sex differences in acute inflammation.

Results: (See table) There were significant sex differences in brachial SBP, brachial DBP, aortic DBP and aortic MAP with higher values in males. (p<0.05). However, there were no statistically significant sex differences in wave separation variables or aortic SBP during acute inflammation, but acute inflammation decrease brachial DBP, aortic SBP, and aortic MAP in all subjects combined, and reflected pulse pressure approached a decline in the entire cohort (p=0.06).

Conclusions: The results suggest that blood pressure, forward and reflected pulse wave pressure exhibited similar responses in males and females during acute inflammation.

	Brachial DBP(mmHg)^†			Aortic DBP(mmHg)^†			Aortic MAP(mmHg)^†			Forward wave pressure(mmHg)			Reflected wave pressure(mmHg)

	Baseline	24 hr Post	48 hr post	Baseline	24 hr Post	48 hr post	Baseline	24 hr Post	48 hr post	Baseline	24 hr Post	48 hr post	Baseline	24 hr Post	48 hr post
Male	69±9	67±9	69±9	70±9	68±9	69±9	87±10	84±9	85±10	29±5	29±5	28±6	19±7	17±7	18±6
Female	66±8^*	63±7	64±7	66±8^*	64±7	64±7	82±11^*	79±8	79±9	27±5	27±5	26±5	17±7	15±5	15±4

*

Different from other time point, p<0.05.

†

Sex difference. Significant at p<0.05.

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Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 174 - 175
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.030 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Sang Ouk Wee
AU  - Abbi Lane
AU  - Kanokwan Bunsawat
AU  - Alexander Rosenberg
AU  - Bo Fernhall
PY  - 2014
DA  - 2014/11/04
TI  - PO-24 SEX DIFFERENCES IN HEMODYNAMIC RESPONSES FOLLOWING ACUTE INFLAMMATION: WAVE SEPARATION ANALYSIS
JO  - Artery Research
SP  - 174
EP  - 175
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.030
DO  - 10.1016/j.artres.2014.09.030
ID  - Wee2014
ER  -

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