Artery Research

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Volume 8, Issue 4, December 2014, Pages 166 - 167

PO-02 EFFECTS OF ACUTE INDUCED INFLAMMATION ON PRESSURE WAVEFORMS: DOES AGE MATTER?

Authors
K. Bunsawata, A.D. Lanb, R.M. Kappusa, S.M. Ranadivec, H. Yand, Sang-Ouk Weea, S. Phillipsa, T. Baynarda, J. Woodsd, R. Motld, B. Fernhalla
aDepartment of Kinesiology, Nutrition, and Rehabilitation, University of Illinois at Chicago, Chicago, IL, USA
bDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA, USA
cDepartment of Anesthesiology, Mayo Clinic, Rochester, MN, USA
dDepartment of Kinesiology, East Carolina University, Greenville, NC, USA
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.008How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The Augmentation index (AIx) is a strong independent predictor of atherosclerosis. Aging is characterized by increased AIx and low grade inflammation. However, the effect of induced systemic inflammation on AIx is unclear.

Purpose: To investigate the effect of acute induced inflammation on wave reflection using wave separation analysis (WSA) in young (YA) vs. old adults (OA) pre-vaccination and 24-hr and 48-hr post vaccination.

Methods: Subjects were 22 YA (female=14; age 25±4 yrs; BMI 23.3±3.0 kg/m2) and 26 OA (female=17; age 63±6 yrs; BMI 29.6±6.3 kg/m2). AIx was assessed using applanation tonometry and followed by wave separation analysis (SphygmoCor, AtCor Medical). CRP and IL-6 were measured using ELISA assays.

Results: Compared to YA, OA had higher baseline aortic pulse pressure (aPP), AIx, AIx@75, central pulse wave velocity (cPWV), reflected wave pressure (RPH), IL-6, and CRP (P<0.05). AIx, AIx@75, and cPWV did not change from baseline, but were higher in OA at all time points (P<0.05). aPP, Forward wave pressure (FPH) and RPH decreased from baseline in OA (P<0.05), but did not change in YA. IL-6 increased from baseline at post 24-hr in YA, but not in OA (P<0.05).

Conclusions: Although acute induced inflammation did not change indices of central arterial stiffness in OA, WSA revealed that FPH and RPH decreased in OA, concomitant with an aPP reduction. It appears that induced inflammation has a greater effect on arterial function and aPP in OA possibly due to greater effects of inflammation on peripheral vasodilatation in this group.

Variables Baseline Post 24-hr Post 48-h Time Age Interaction
aPP (mmHg) YA 30±6 32±6 33±6 0.730 <0.001 0.001
OA 43±10# 41±10# 39±9#,*
AIx YA 7.80±11.26 3.05±11.14 4.60±11.54 0.085 <0.001 0.185
OA 34.52±10.45# 34.40±13.09 32.56±8.33
AIx@75 YA −1.40±12.3 −4.35±11.13 −5.05±10.61 0.132 <0.001 0.434
OA 28.24±9.89# 28.56±10.09 26.68±7.37
cPWV YA 5.38±0.76 5.48±0.90 5.50±1.05 0.681 <0.001 0.885
OA 7.61±1.76# 8.04±1.97 7.69±1.33
FPH (mmHg) YA 27±5 29±5 29±5 0.682 1.812 0.010
OA 28±5 25±4#,* 25±5
RPH (mmHg) YA 13±4 13±4 14±3 0.002 <0.001 <0.001
OA 22±6# 19±6#,* 18±5#,*
IL-6 (ng/mL) YA 0.89±0.57 2.29±2.14* 1.14±1.33 <0.001 0.001 0.001
OA 2.18±1.47# 2.60±1.85 2.23±1.46#
CRP (mg/L) YA 1.03±1.01 1.28±0.95 1.62±1.19 <0.001 0.002 0.492
OA 2.60±2.19# 3.94±3.76 4.38±4.13

Data are mean±SD. BMI, body mass index; VO2peak, peak oxygen consumption; aPP, aortic pulse pressure; AIx, augmentation index; AIx@75, augmentation index corrected for heart rate 75 bpm; cPWV, central pulse wave velocity; FPH, forward pulse height; RPH, reflected pulse height;IL-6, interleukin-6;CRP, C-reactive protein.

*

Significantly different than baseline (P<0.05).

#

Significantly different than young adults (P<0.05).

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Journal
Artery Research
Volume-Issue
8 - 4
Pages
166 - 167
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.008How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - K. Bunsawat
AU  - A.D. Lan
AU  - R.M. Kappus
AU  - S.M. Ranadive
AU  - H. Yan
AU  - Sang-Ouk Wee
AU  - S. Phillips
AU  - T. Baynard
AU  - J. Woods
AU  - R. Motl
AU  - B. Fernhall
PY  - 2014
DA  - 2014/11/04
TI  - PO-02 EFFECTS OF ACUTE INDUCED INFLAMMATION ON PRESSURE WAVEFORMS: DOES AGE MATTER?
JO  - Artery Research
SP  - 166
EP  - 167
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.008
DO  - 10.1016/j.artres.2014.09.008
ID  - Bunsawat2014
ER  -