Artery Research

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Volume 8, Issue 4, December 2014, Pages 167 - 168

PO-05 BUFFERING OF CAROTID ARTERY PRESSURE AND FLOW PULSATILITY DURING COGNITIVE ENGAGEMENT IN HEALTHY ADULTS

Authors
Kevin S. Heffernana, Nicole L. Spartanoa, Jacqueline A. Augustinea, Wesley K. Leffertsa, William E. Hughesa, Gary F. Mitchelld, Randall S. Jorgensenb, Brooks B. Gumpc
aDepartment of Exercise Science, Syracuse University, Syracuse, NY, USA
bDepartment of Psychology, Syracuse University, Syracuse, NY, USA
cDepartment of Public Health, Syracuse University, Syracuse, NY, USA
dCardiovascular Engineering, Inc., Norwood, MA, USA
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Excessive hemodynamic pulsatility may have a detrimental effect on neural function and affect NVC. Arterial stiffness is a prominent determinant of pulsatility in the brain.1, 2

Objectives: We explored changes in arterial stiffness and cerebrovascular hemodynamic pulsatility during cognitive engagement in healthy adults.

Methods: Twenty-seven adults (age 39 ± 3 yrs, BMI 24±1 kg/m2) underwent Doppler ultrasonography and applanation tonometry of the common carotid artery (CCA) to derive 1) CCA elastic modulus (Ep) and β-stiffness index; 2) CCA flow pulsatility index (PI); 3) CCA pulse pressure (PP), and 4) CCA augmentation index (AIx). Transcranial Doppler was used to assess cerebral PI at the middle cerebral artery (MCA). All measures were made simultaneously at rest and during a 4-minute Stroop task.

Results: CCA PI was reduced (p<0.05) while MCA PI was unchanged (p>0.05) during Stroop. Brachial PP increased during Stroop (p<0.05) while CCA PP was unchanged (p>0.05). Similarly, CCA Ep (p>0.05) and β-stiffness (p>0.05) were unchanged. CCA AIx increased (p<0.05).

Conclusion: Carotid pressure pulsatility and cerebral flow pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid stiffness does not change suggesting that factors other than the elastic properties of the vessel moderate cerebrovascular pulsatility during cognitive engagement.

Variable Baseline Stroop P–value
Brachial pulse pressure, mmHg 43 ± 1 46 ± 1 0.002
Carotid pulse pressure, mmHg 36 ± 1 35 ± 1 0.324
Carotid β-stiffness, aU 4.4 ± 0.4 4.2 ± 0.3 0.224
Carotid Ep, kPa 54.5 ± 5.5 53.8 ± 4.9 0.670
Carotid pressure AIx, % 1 ± 4 13 ± 4 0.001
Carotid distension AIx, % 4 ± 2 8 ± 2 0.001
Carotid mean diameter, mm 5.62 ± 0.13 5.74 ± 0.13 0.010
Carotid pulsatility index 1.75 ± 0.06 1.57 ± 0.06 0.016
Cerebral pulsatility index 0.75 ± 0.02 0.75 ± 0.01 0.841
Table 1

Hemodynamic and vascular parameters at rest and during Stroop task.

References

1.GF Mitchell, MA van Buchem, S Sigurdsson, JD Gotal, MK Jonsdottir, O Kjartansson, M Garcia, T Aspelund, TB Harris, V Gudnason, and LJ Launer, Arterial stiffness, pressure and flow pulsatility and brain structure and function: The age, gene/environment susceptibility–reykjavik study, Brain, Vol. 134, 2011, pp. 3398-3407.
2.T Tarumi, M Ayaz Khan, J Liu, BM Tseng, R Parker, J Riley, C Tinajero, and R Zhang, Cerebral hemodynamics in normal aging: Central artery stiffness, wave reflection, and pressure pulsatility, Journal of cerebral blood flow and metabolism, 2014.
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Journal
Artery Research
Volume-Issue
8 - 4
Pages
167 - 168
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kevin S. Heffernan
AU  - Nicole L. Spartano
AU  - Jacqueline A. Augustine
AU  - Wesley K. Lefferts
AU  - William E. Hughes
AU  - Gary F. Mitchell
AU  - Randall S. Jorgensen
AU  - Brooks B. Gump
PY  - 2014
DA  - 2014/11/04
TI  - PO-05 BUFFERING OF CAROTID ARTERY PRESSURE AND FLOW PULSATILITY DURING COGNITIVE ENGAGEMENT IN HEALTHY ADULTS
JO  - Artery Research
SP  - 167
EP  - 168
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.011
DO  - 10.1016/j.artres.2014.09.011
ID  - Heffernan2014
ER  -