P3.1 BENEFICIAL EFFECTS OF HYPERTRIGLYCERIDEMIA TREATMENT ON MICROVASCULAR ENDOTHELIAL FUNCTION IN TREATED HYPERTENSIVE PATIENTS

M. Casanova; V. Menezes; A. Cunha; M. Burlá; F. Medeiros; W. Oigman; M. Neves

doi:10.1016/j.artres.2014.09.112

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 8, Issue 4, December 2014, Pages 136 - 136

P3.1 BENEFICIAL EFFECTS OF HYPERTRIGLYCERIDEMIA TREATMENT ON MICROVASCULAR ENDOTHELIAL FUNCTION IN TREATED HYPERTENSIVE PATIENTS

Authors

M. Casanova^a, V. Menezes^a, A. Cunha^a, M. Burlá^b, F. Medeiros^c, W. Oigman^a, M. Neves^a

^aUniversidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

^bUniversidade Federal Fluminense, Rio de Janeiro, Brazil

^cUniversidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.112 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: The relationship between increased levels of triglycerides (TG) and cardiovascular (CV) risk is controversial, and the effects on endothelial function are also unclear.

Objective: To investigate the effects of hypertriglyceridemia treatment on vascular function in treated hypertensive patients.

Methods: Thirty-six hypertensive patients with TG levels 150 to 499 mg/dl, both genders, aged 40–65 years, were randomized to receive active treatment (fish oil or fibrate) or placebo for 3 months. Systolic and diastolic blood pressure (SBP and DBP), brachial flow-mediated dilation (FMD), reactive hyperemia index (RHI) by peripheral artery tonometry, pulse wave velocity (PWV), carotid intima-media thickness (IMT) and central hemodynamic parameters were determined at baseline and after 3-month intervention.

Results: Treatment group presented significant decrease in SBP (139±17 to 134±12mmHg, p<0.05), DBP (86±11 to 81±9mmHg, p<0.05), TG levels (255±73 to 156±77mg/dl, p<0.001), carotid-radial PWV (10.9±1.8 to 10.2±1.2m/s, p<0.05) and aortic SBP (131±16 to 125±10mmHg, p<0.05) compared with control group. Treatment group showed significantly improvement in RHI (1.87±0.36 to 2.13±0.49 units, p<0.05). No significant effect was observed on FMD and carotid IMT. RHI increase was correlated with TG reduction (r=−0.40, p=0.043) and baseline TG/HDL (r=0.44, p=0.023), RHI (r=0.40, p=0.041) and aortic pulse pressure (r=0.45, p=0.020). After multiple linear regression, RHI improvement was only associated to TG decrease (B=−0.001, p=0.043) and baseline aortic pulse pressure (B=−0.012, p=0.023).

Conclusion: The treatment of hypertriglyceridemia was associated with improvement in microvascular endothelial function in treated hypertensive patients suggesting that TG levels reduction may have vascular protective effects in these patients.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 136 - 136
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.112 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - M. Casanova
AU  - V. Menezes
AU  - A. Cunha
AU  - M. Burlá
AU  - F. Medeiros
AU  - W. Oigman
AU  - M. Neves
PY  - 2014
DA  - 2014/11/04
TI  - P3.1 BENEFICIAL EFFECTS OF HYPERTRIGLYCERIDEMIA TREATMENT ON MICROVASCULAR ENDOTHELIAL FUNCTION IN TREATED HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 136
EP  - 136
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.112
DO  - 10.1016/j.artres.2014.09.112
ID  - Casanova2014
ER  -

download .riscopy to clipboard