Artery Research

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Volume 8, Issue 4, December 2014, Pages 133 - 133

P2.1 CAROTID PLAQUE MICROVASCULATURE ASSESSED USING DYNAMIC CONTRAST-ENHANCED MRI: COMPARING DIFFERENT REGIONS OF THE VASCULAR WALL

Authors
R. Van Hoofa, b, E. Hermelinga, c, N. Wijnena, F. Schreudera, M. Truijmana, S. Vooa, c, J. Cleutjensa, c, J. Sluimera, c, S. Heenemana, c, R. Oostenbruggea, c, J.-W. Daemena, c, M. Daemena, J. Wildbergera, c, M. Kooia, c
aMaastricht University Medical Center, Maastricht, The Netherlands
bAcademic Medical Center, Amsterdam, The Netherlands
cMaastricht University, Maastricht, The Netherlands
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Pharmacokinetic modeling in Dynamic Contrast-Enhanced (DCE-)MRI has been introduced to non-invasively assess microvasculature in carotid atherosclerotic plaques, a marker for plaque vulnerability. The main model-parameter, Ktrans, can be assessed in the outer region of the vessel (adventitia) or in the entire vessel wall (including plaque and adventitia) and already showed association with histology and features of plaque vulnerability, respectively. We investigated systematically the correlation between Ktrans of these various regions of the vascular wall and their individual correlation with histology as gold standard.

Methods: 45 symptomatic patients with 30–99% carotid stenosis underwent 3T DCE-MRI (0.1mmol/kg Gadobutrol, 0.5ml/sec). Quantitative modeling was performed to determine Ktrans of the entire vessel wall, adventitia, and plaque region, separately. For 10 patients, CD31 immunohistochemistry was performed on specimens (containing mainly plaque) removed during carotid endarterectomy to quantify the endothelial microvessel area.

Results: Adventitial Ktrans showed weak correlation with plaque Ktrans (r=0.64, p<0.001) and was 17.3% higher (p<0.001), coinciding with decreased uncertainty in parameter estimation (p=0.015). Significant positive correlation between the endothelial microvessel area and adventitial Ktrans (r=0.854, p=0.002), but not from the plaque (r=0.438, p=0.2) was observed. Entire vessel wall Ktrans showed intermediate results for the various analyses.

Discussion: Although Ktrans assessed over various regions within the vascular wall are correlated, absolute values differ significantly. Adventitial Ktrans seems to be a better measure for plaque microvasculature compared to other vascular regions, coinciding with a lower uncertainty in parameter estimation. Comparison with histology in a larger number of patients is recommended for definitive conclusions.

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Journal
Artery Research
Volume-Issue
8 - 4
Pages
133 - 133
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - R. Van Hoof
AU  - E. Hermeling
AU  - N. Wijnen
AU  - F. Schreuder
AU  - M. Truijman
AU  - S. Voo
AU  - J. Cleutjens
AU  - J. Sluimer
AU  - S. Heeneman
AU  - R. Oostenbrugge
AU  - J.-W. Daemen
AU  - M. Daemen
AU  - J. Wildberger
AU  - M. Kooi
PY  - 2014
DA  - 2014/11/04
TI  - P2.1 CAROTID PLAQUE MICROVASCULATURE ASSESSED USING DYNAMIC CONTRAST-ENHANCED MRI: COMPARING DIFFERENT REGIONS OF THE VASCULAR WALL
JO  - Artery Research
SP  - 133
EP  - 133
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.097
DO  - 10.1016/j.artres.2014.09.097
ID  - VanHoof2014
ER  -