1.1 GENOME WIDE ASSOCIATION SCAN IDENTIFIES LOCI FOR ARTERIAL STIFFNESS IN YOUNG HEALTHY ADULTS

Yasmin; C. McEniery; S. Cleary; B. Lam; H. Kuper; Y. Endo; S. Kinra; D. Chen; G. Chandak; J. Deanfield; D. Lawlor; J. Cockcroft; I. Wilkinson; K. O’Shaughnessy

doi:10.1016/j.artres.2014.09.050

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Volume 8, Issue 4, December 2014, Pages 122 - 122

1.1 GENOME WIDE ASSOCIATION SCAN IDENTIFIES LOCI FOR ARTERIAL STIFFNESS IN YOUNG HEALTHY ADULTS

Authors

Yasmin^a, C. McEniery^a, S. Cleary^a, B. Lam^a, H. Kuper^b, Y. Endo^b, S. Kinra^b, D. Chen^a, G. Chandak^c, J. Deanfield^d, D. Lawlor^e, J. Cockcroft^f, I. Wilkinson^a, K. O’Shaughnessy^a

^aUniversity of Cambridge, Cambridge, UK

^bLondon School of Hygiene & Tropical Medicine, London, UK

^cCentre for Cellular & Molecular Biology, Hyderabad, India

^dUniversity College London, London, UK

^eBristol University, Bristol, UK

^fCardiff University, Cardiff, UK

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.050 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Premature arterial stiffening is an important and independent predictor of cardiovascular risk. Stiffness is heritable, but the precise molecular pathways regulating it are poorly understood. We aimed to identify possible genetic risk loci for arterial stiffness in young healthy adults (<25 years) at low cardiovascular risk, and explore top signals in other populations.

Methods: Demographic and haemodynamic data including aortic pulse wave velocity (aPWV) were recorded. Genome wide association scan (GWAS) was performed in ACCT individuals at extremes of high and low aPWV (n=1200) using Illumina 610K beadarrays. Top 16 signals validated in age matched cohorts (ALSPAC: n=2963; Hyderabad: n=686; and remainder of ACCT: n=910). Taqman and Sequenom SNP assays used for replication studies. SNPs were tested for their association with aPWV after adjusting for covariates.

Results: GWAS analysis revealed a number of SNPs associating with aPWV. Overall, 7 SNPs reached GW significance (p<10⁻⁸), 41 had threshold values of p<10⁻⁷p<10⁻⁶ and 220 had nominal value of 10⁻⁵. The beta value for strongest associations ranged from 0.38 to 0.17 per allele, and overall explained just under 5% of total variance; signals identified mapped to either intronic or intergenic regions. GWAS SNPs were successfully replicated in ALSPAC, Hyderabad and remainder of ACCT. The combined analysis of three studies revealed seven genetic loci associated significantly with aPWV (p<10⁻⁹).

Conclusions: We identified, several genetic loci that, individually and in aggregate, substantially associate with risk of premature large artery stiffening (LAS). Fine mapping these signals will offer important insights into the patho-physiology of LAS.

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Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 122 - 122
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.050 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Yasmin
AU  - C. McEniery
AU  - S. Cleary
AU  - B. Lam
AU  - H. Kuper
AU  - Y. Endo
AU  - S. Kinra
AU  - D. Chen
AU  - G. Chandak
AU  - J. Deanfield
AU  - D. Lawlor
AU  - J. Cockcroft
AU  - I. Wilkinson
AU  - K. O’Shaughnessy
PY  - 2014
DA  - 2014/11/04
TI  - 1.1 GENOME WIDE ASSOCIATION SCAN IDENTIFIES LOCI FOR ARTERIAL STIFFNESS IN YOUNG HEALTHY ADULTS
JO  - Artery Research
SP  - 122
EP  - 122
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.050
DO  - 10.1016/j.artres.2014.09.050
ID  - 2014
ER  -

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