Artery Research

Volume 2, Issue 3, August 2008, Pages 117 - 117

P2.44 INCREASED PULSE PRESSURE IS ASSOCIATED WITH LONG LEFT VENTRICULAR EJECTION DURATION IN ISOLATED SYSTOLIC HYPERTENSIVES

Authors
K.D. Reesink, E. Hermeling, J. Waltenberger, A.P.G. Hoeks
Cardiovascular Research Institute Maastricht, Maastricht, Netherlands
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.410How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Apart from stiff arteries, increased pulse pressure is associated with increased left ventricular (LV) contractility. We investigated whether elevated LV performance can be derived from carotid artery diameter waveforms in hypertensives.

Methods: We obtained common carotid artery (CCA) diameter waveforms by ultrasound in 8 isolated systolic hypertension (ISH) patients (sys/dia: 154±17/77±13 mmHg, age 70±8 yrs). By dedicated signal processing we obtained, with good precision (<10%), left ventricular isovolumic contraction (ICT) and ejection durations (ET) from the diameter curve, as well as diastolic diameter (Dd), distension (ΔD), relative distension (ΔD/Dd), and distensibility (DC) and compliance coefficients (CC).

Results: Dd was 7.9±1.0 mm, ΔD was 0.30±0.12 mm, ΔD/Dd thus 4±2%; pulse pressure was 77±16 mmHg. DC was 10±5 MPa−1 and CC was 0.5±0.2 mm2/kPa, clearly linking the elevated pulse pressure to reduced arterial stiffness. Heart rate was 76±18 min−1 while LV ICT and ET were 40±7 ms and 311±46 ms, respectively. LV dP/dtmax, estimated from the diastolic blood pressure-to-ICT ratio, was 1991±566 mmHg/s, suggesting no conspicuous contribution of LV contractility to increased pulse pressure in ISH. Within the group, however, there was a large spread in LV performance primarily related to ET and heart rate. Interestingly, ET showed a strong correlation with pulse pressure (r2=0.85, p<0.01), suggesting long ejection duration contributes to high pulse pressure in some patients.

Conclusions: Increased left ventricular performance, as reflected by ejection duration, can be observed and discriminated in isolated systolic hypertensives by diameter waveform analysis.

Journal
Artery Research
Volume-Issue
2 - 3
Pages
117 - 117
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.410How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - K.D. Reesink
AU  - E. Hermeling
AU  - J. Waltenberger
AU  - A.P.G. Hoeks
PY  - 2008
DA  - 2008/09/15
TI  - P2.44 INCREASED PULSE PRESSURE IS ASSOCIATED WITH LONG LEFT VENTRICULAR EJECTION DURATION IN ISOLATED SYSTOLIC HYPERTENSIVES
JO  - Artery Research
SP  - 117
EP  - 117
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.410
DO  - 10.1016/j.artres.2008.08.410
ID  - Reesink2008
ER  -