Artery Research

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Volume 2, Issue 3, August 2008, Pages 118 - 119

P2.51 PRECLINICAL ATHEROSCLEROTIC DISEASE AND METABOLIC SYNDROME: A PREDIABETES STAGE?

Authors
P. Forcada1, C. Kotliar1, S. Obregon1, G. Millet1, J. Guerrieri1, O. Montana2, C. Schulte2, D. Turri1
1Hospital Universitario Austral, Pilar, Buenos Aires, Argentina
2Clinica Dim, Buenos Aires, Argentina
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.417How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: In ESH/ESC 07 Guidelines, Metabolic Syndrome (MS) and subclinical vascular disease (VD) are stressed as important markers of high risk in asymptomatic subjects. We compared the severity of VD by ultrasonography in patients (p.) with MS and Diabetes Mellitus (DM) and control (C) p. to analyze the relationship between the metabolic condition and the severity of VD.

Methods: We did in the same procedure 1) CIMT 2) Plaques characterization, 3) PWV and 4) FMD with a strict quality control. We set a score (VS) from 0 to 5 according to the severity of the VD. The CV Risk using Framingham score (FS) was also obtained from medical records.

Results: We performed a cross sectional, observational study on 292 matched p., 125 C without dyslipemia or overweight, 138 with MS (according ATP III criteria) and 29 with DM..

Parameter C (n= 125) MS (n= 138) DBT (n= 29) p
Age 54 ± 12 54 ± 11 51 ± 10 NS
Sex (% males) 70 64 52 NS
SBP (mmHg) 141 ± 18 141 ± 16 142 ± 10 NS
DBP (mmHg) 85 ± 11 86 ± 9 87 ± 10 NS
HR (bpm) 69 ± 9 71 ± 10 74 ± 10 NS
% abnormal IMT 19 33 41 .012
% Plaques 22 54 55 < 001
%Abnormal FMD 33 39 45 NS
%Abnormal PWV 30 38 65 .002
FS (mean) 10 ± 8 10 ± 6 25 ± 12 < 001
VS (mean) 2,1 ± 1,4 2,5 ± 1,4 3,0 ± 1,7 .004

Conclusions: 1- In a selected population of matched p. according to age, sex and BP, there seems to be an increase in the degree of VD when MS is present. 2- The pattern of VD in MS p. was close to that in DM p. consistent with the described increase in CV risk in MS.3-A VS may be useful in the clinical practice.

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Journal
Artery Research
Volume-Issue
2 - 3
Pages
118 - 119
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.417How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - P. Forcada
AU  - C. Kotliar
AU  - S. Obregon
AU  - G. Millet
AU  - J. Guerrieri
AU  - O. Montana
AU  - C. Schulte
AU  - D. Turri
PY  - 2008
DA  - 2008/09/15
TI  - P2.51 PRECLINICAL ATHEROSCLEROTIC DISEASE AND METABOLIC SYNDROME: A PREDIABETES STAGE?
JO  - Artery Research
SP  - 118
EP  - 119
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.417
DO  - 10.1016/j.artres.2008.08.417
ID  - Forcada2008
ER  -