P2.03 EARLY INFLAMMATION CAN PREDICT ARTERIAL STIFFNESS: A 15-YEAR LONGITUDINAL STUDY OF 102 PATIENTS WITH RHEUMATOID ARTHTRITIS
- DOI
- 10.1016/j.artres.2008.08.369How to use a DOI?
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Objectives: To examine impact of early inflammation in RA on the development of CV disease.
Methods: 238 patients with RA of less than 4 years duration at inclusion in 1992 have been followed longitudinally. At the 15-year follow-up we performed Pulse wave analysis assessments including measurements of AI and PWV using the Sphygmocor apparatus (Atcor). The measurements were corrected for age, sex , MAP and heart rate. The AI was also corrected for height. Patients aged over 70 at the follow-up were omitted from the PWV analysis. Baseline measures of disease activity were then entered consecutively into the model.
Results: 102 patients were eligible for analysis of AI, 76 for PWV. Table 1 presents the adjusted univariate ß coefficients (CI)/p for the prediction of AI and PWV. In the multivariate model anti-CCP remained a significant predictor of AI p=0.01. R2 adjusted increased from 0.43 to 0.46. In an alternative model without antiCCP, CRP remained a significant predictor p=0.04, R2 adjusted 0.45. In the multivariate model CRP remained a significant predictor of PWV p=0.02. R2 adjusted increased from 0.50 to 0.53.
| Table1 Variable | AI (dependent variable) | PWV(dep. variable) |
|---|---|---|
| CRP | 0.12 (0.00–0.25)/0.04 | 0.03(0.01–0.6)/0.02 |
| ESR | 0.06 (−0.008–0.14)/0.08 | 0.001 (−0.02–0.02)/0.93 |
| IgMRF | 0.02 (0.002–0.03)/0.03 | 0.002(−0.003–0.003)/0.89 |
| Anti-CCP | 0.02(0.004–0.03)/0.01 | 0.003(−0.003–0.003)/0.84 |
| HAQ (health status) | 1.67(−0.89–4.22)/0.20 | 0.46 (−0.05–0.99)/0.08 |
| Sharp (radiographic) | 0.09(−0.06–0.25)/0.23 | −0.01 (−0.04–0.02)/0.60 |
Conclusion: Inflammation early in the disease course is associated with an increased augmentation index and pulse wave velocity after 15 years.
Cite this article
TY - JOUR AU - S.A. Provan AU - K. Angel AU - A.G. Semb AU - P. Mowinckel AU - S. Agewall AU - D. Atar AU - T.K. Kvien PY - 2008 DA - 2008/09/15 TI - P2.03 EARLY INFLAMMATION CAN PREDICT ARTERIAL STIFFNESS: A 15-YEAR LONGITUDINAL STUDY OF 102 PATIENTS WITH RHEUMATOID ARTHTRITIS JO - Artery Research SP - 107 EP - 107 VL - 2 IS - 3 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2008.08.369 DO - 10.1016/j.artres.2008.08.369 ID - Provan2008 ER -