P1.54 THE RELATIONSHIP OF THE INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM TO CARDIOVASCULAR STRUCTURE AND FUNCTION IN WOMEN
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Introduction: IGF-I and its binding proteins (BP) may modulate cardiovascular risk, from young ages. We examined relationships of IGF system indices (IGF-I, -BP-1, BP-3, IGF-I/BP-3 ratio) to cardiac and vascular structure & function across the whole vascular bed.
Methods: 193 women in our Manchester Mothers’ Cardiovascular (CVS) study followed from an index pregnancy aged 32±5y had fasting blood samples, anthropometry, echocardiography, aortic pulse wave velocity and heat augmented laser doppler flowmetry (LDF). In a smaller subgroup (n=29), subcutaneous small artery structure and function was assessed ex-vivo by wire myography. IGF-I and IGFBP-3 were assayed by Elisa, and IGFBP-1 by radio-immunoassay.
Results: On multiple regression analysis, adjusting for age, ethnicity, smoking history, BMI, systolic blood pressure, fasting glucose, total cholesterol and triglycerides, IGF-I, IGFBP1 and the IGF-I/BP-3 ratio were independently related to CVS parameters as follows:
| CVS parameter | IGF system | Beta | 95% CI of Beta | p |
|---|---|---|---|---|
| LV Posterior Wall thickness | IGF-I/BP-3 ratio | −0.005 | −0.009 to 0.00 | 0.04 |
| Proximal aortic distensibility (echo) | IGF-I/BP-3 ratio | −0.014 | −0.028 to 0.00 | 0.05 |
| Heat augmented microcirculatory flow (LDF) | IGF-I/BP-3 ratio | 0.05 | 0.007 to 0.094 | 0.03 |
| Ln IGFBP1 | −0.66 | −1.09 to −0.22 | 0.004 | |
| Subcutaneous small artery media: lumen ratio(n=29) | Total IGF-I | 0.19 | 0.07 to 0.31 | 0.003 |
| IGF-I/BP-3 ratio | 2.09 | 1.54 to 2.63 | <0.001 | |
| Ln IGFBP1 | −28.0 | −44.85 to −11.17 | 0.002 |
Conclusion: In relatively young women, higher concentrations of IGF-I, ‘free’ IGF-I (= IGF-I/BP-3 ratio) and of IGFBP-1 had marked influences on cardiac, large and small vessel structure and function.
Cite this article
TY - JOUR AU - M. Banerjee AU - K. Siddals AU - V. Charlton-Menys AU - M.J. Gibson AU - C. Austin AU - J.K. Cruickshank PY - 2008 DA - 2008/09/15 TI - P1.54 THE RELATIONSHIP OF THE INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM TO CARDIOVASCULAR STRUCTURE AND FUNCTION IN WOMEN JO - Artery Research SP - 105 EP - 105 VL - 2 IS - 3 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2008.08.361 DO - 10.1016/j.artres.2008.08.361 ID - Banerjee2008 ER -