Artery Research

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Volume 2, Issue 3, August 2008, Pages 93 - 93

P1.04 THE INFLUENCE OF QUINAPRIL ON ARTERIAL STIFFNESS, BLOOD VISCOSITY AND ARTERIAL SHEAR STRESS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION

Authors
M. Rajzer, W. Wojciechowska, M. Klocek, M. Brzozowska-Kiszka, K. Kawecka-Jaszcz
Department of Cardiology and Hypertension, Medical College, Jagiellonian University, Krakow, Poland
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.312How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: to analyze the influence of quinapril on aortic PWV, whole blood viscosity (WBV), shear stress in the ascending aorta (AA) and common carotid artery (CCA), prometaloproteinase-1 (proMMP-1) and its tissue inhibitor (TIMP-1) plasma concentration in patients with essential arterial hypertension (HT).

Methods: 55 patients, (mean age 55,8 ± 13,8 yrs.) with HT 1 and 2 gr. were treated with quinapril in stepwise increased doses from 10 to 40 mg/d till BP goal <140/90 mmHg was achieved. At baseline and then after 3 and 6 months of treatment PWV, WBV, proMMP-1 and TIMP-1 were determined. Shear stress in AA and CCA was calculated from WBV, internal vessel diameter and blood flow velocity (Vmax) measured ultrasonographycally.

Results: After 6 months of treatment by quinapril we observed decrease of BP (155.6/92.0 mmHg vs. 135.9/82.9 mmHg, p<0.001), PWV (10.35 m/s vs. 9.64 ms, p<0.001), WBV (5.14 cP vs. 4.86 cP, p<0.05) and TIMP-1 (111.0 ng/ml vs. 94.1 ng/ml, p<0.001) and increase of Vmax in AA (127.1 cm/s vs.131.3 cm/s, p<0.05, Vmax in CCA (69.9cm/s vs. 78.4 cm/s, p<0.05) and shear stress in CCA (22.2 dyne/cm2 vs. 24.7 dyne/cm2 , p<0.05). Significant positive correlation was observed for PWV and TIMP-1, and negative correlations for PWV and Vmax in AA, PWV and Vmax in CCA, as well as PWV and shear stress in CCA.

Conclusions: Quinapril reduces arterial stiffness by inhibition of collagen metabolism. This effect is mediated by influence on arterial shear stress.

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Journal
Artery Research
Volume-Issue
2 - 3
Pages
93 - 93
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.312How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Rajzer
AU  - W. Wojciechowska
AU  - M. Klocek
AU  - M. Brzozowska-Kiszka
AU  - K. Kawecka-Jaszcz
PY  - 2008
DA  - 2008/09/15
TI  - P1.04 THE INFLUENCE OF QUINAPRIL ON ARTERIAL STIFFNESS, BLOOD VISCOSITY AND ARTERIAL SHEAR STRESS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION
JO  - Artery Research
SP  - 93
EP  - 93
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.312
DO  - 10.1016/j.artres.2008.08.312
ID  - Rajzer2008
ER  -