Artery Research

Volume 2, Issue 3, August 2008, Pages 88 - 89

04.02 EXAMINATION OF EFFECTS OF TNF-ALPHA ANTAGONISTS ON ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND RELATED ARTHROPATHIES: A CONTROLLED STUDY

Authors
K. Angel1, S. Provan2, T.K. Kvien1, D. Atar1
1University of Oslo, Oslo, Norway
2Diakonhjemmet Hospital, Oslo, Norway
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.295How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: It has been suggested that the chronic inflammatory state of rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) contributes to accelerated atherosclerosis. The aim of this study was to evaluate the effect of anti-TNF-α therapy on arterial stiffness in patients with RA, AS and PsA.

Methods: 35 patients (RA=17, AS=12 and PsA=6) who started with anti-TNF-α therapy (adalimumab=15, etanercept=12, infliximab=8) and a non-treatment group of 25 patients (RA=12, AS=9 and PsA=4) underwent measurements of aortic Pulse Wave Velocity (aPWV) and Augmentation Index (AIx) at baseline and after 3 months (Sphygmocor). Patients in the non-treatment group had the same indications for anti-TNF-α therapy, but had to postpone their initiation due to positive Mantoux-test or planned operations.

Results: Patients who started anti-TNF-α therapy had a significant decrease in aPWV (−0.465 m/s) whereas the patients in the control group had no change (+0.061 m/s, p=0.002 for between group changes). Between group differences for AIx were not observed (change −0.62% and +0.44%, p=0.48). As expected, a significant reduction in CRP (−9.2 mg/l, p=0.011) and DAS28 for the RA patients (−0.73, p=0.002) was observed in the treatment group, but we did not find significant correlations between change in aPWV and CRP in the entire treatment group (r=0.055, p=0.785) and between change in aPWV and DAS28 in the RA group (r=0.091, p=0.737).

Conclusion: These findings indicate that anti-TNF-alpha therapy ameliorates functional parameters of early atherosclerosis. However, changes in aPWV were not correlated to improvement in markers of inflammatory activity.

Journal
Artery Research
Volume-Issue
2 - 3
Pages
88 - 89
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.295How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - K. Angel
AU  - S. Provan
AU  - T.K. Kvien
AU  - D. Atar
PY  - 2008
DA  - 2008/09/15
TI  - 04.02 EXAMINATION OF EFFECTS OF TNF-ALPHA ANTAGONISTS ON ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND RELATED ARTHROPATHIES: A CONTROLLED STUDY
JO  - Artery Research
SP  - 88
EP  - 89
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.295
DO  - 10.1016/j.artres.2008.08.295
ID  - Angel2008
ER  -