Artery Research

Volume 2, Issue 3, August 2008, Pages 88 - 88

03.04 MECHANICAL AND STRUCTURAL CHARACTERISTICS OF CAROTID PLAQUES: ANALYSIS BY MULTI-ARRAY ECHOTRACKING SYSTEM AND MRI

Authors
H. Beaussier1, O. Naggara2, D. Calvet2, R. Joannides3, M. Iacob3, B. Laloux1, E. Bozec1, E. Guegan-Massardier3, A. Triquenot-Bagan3, I. Masson1, C. Oppenheim2, P. Boutouyrie1, S. Laurent1
1Hôpital Europeen Georges Pompidou, Paris, France
2Centre hospitalier Sainte Anne, Paris, France
3CHU Rouen, Rouen, France
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.292How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Combining functional and structural approaches may improve the predictive value for plaque rupture and ischemic events. Two distinct patterns were previously determined along the common carotid artery (CCA) (Paini et al. Stroke 2007): Pattern A (larger radial strain at the plaque level than at adjacent CCA) and its opposite, Pattern B.

Aim: To correlate arterial mechanics and composition of an atherosclerotic plaque at the site of the CCA.

Method: 27 patients with carotid stenosis and an atherosclerotic plaque on the ipsilateral CCA were included: 18 asymptomatics (AS) and 9 symptomatics (S, i.e. with previous ischemic stroke). Mechanical parameters were measured at 127 sites on a 4 cm long CCA segment by a novel non-invasive echotracking system (ArtLab®) and plaque composition was determined by non invasive magnetic resonance imaging (MRI).

Results: There was a trend for pattern A (21 patients) being more often associated with “simple” plaque (i.e. AHA stage I-III) than complex plaque (AHA stage IV-VII), by contrast to pattern B (25 patients) (chi square P=0.054). Pattern B was more frequently observed in S than AS patients (75% vs 43%, P<0.04). In S patients, plaques were characterized by an outward remodeling (increased external diameter and no change in internal diameter) whereas AS plaques grew according to an inward remodeling.

Conclusion: Patients with previous ischemic stroke had a stiffer carotid at the level of the plaque and present a more “complex” plaque composition than asymptomatic patients. Pattern B and complex plaque composition may lead to a higher risk of rupture.

Journal
Artery Research
Volume-Issue
2 - 3
Pages
88 - 88
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.292How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - H. Beaussier
AU  - O. Naggara
AU  - D. Calvet
AU  - R. Joannides
AU  - M. Iacob
AU  - B. Laloux
AU  - E. Bozec
AU  - E. Guegan-Massardier
AU  - A. Triquenot-Bagan
AU  - I. Masson
AU  - C. Oppenheim
AU  - P. Boutouyrie
AU  - S. Laurent
PY  - 2008
DA  - 2008/09/15
TI  - 03.04 MECHANICAL AND STRUCTURAL CHARACTERISTICS OF CAROTID PLAQUES: ANALYSIS BY MULTI-ARRAY ECHOTRACKING SYSTEM AND MRI
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.292
DO  - 10.1016/j.artres.2008.08.292
ID  - Beaussier2008
ER  -