Artery Research

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Volume 1, Issue S1, June 2006, Pages S23 - S23

02.03 AORTIC STIFFNESS AND WAVE REFLECTIONS ARE INCREASED IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Authors
R. Sabit*1, C.E. Bolton1, P.H. Edwards1, I.B. Wilkinson2, J.R. Cockcroft3, D.J. Shale1
1Department of Respiratory Medicine, Llandough Hospital, Cardiff University, Penarth, Vale of Glamorgan, United Kingdom,
2Department of Clinical Pharmacology, University of Cambridge, Cambridge, United Kingdom,
3Department of Cardiology, Cardiff University, Cardiff, Vale of Glamorgan, United Kingdom
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70006-6How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Patients with COPD are at greater cardiovascular risk, even after allowing for confounding risk factors such as smoking. Arterial stiffness is an independent predictor of cardiovascular events. We have therefore assessed arterial stiffness in patients with COPD.

Methods: Patients with COPD (n = 75), 42 male were studied when clinically stable, together with 42 age and gender matched healthy smokers (HS). The degree of airways obstruction was assessed using spirometry. Circulating IL-6 and TNFα soluble receptors (sr) I&II in all subjects and arterialised capillary pO2 in patients were measured. Augmentation index (AIx) and Aortic pulse wave velocity (APWV) were determined as measures of wave reflections and aortic stiffness respectively using the Sphygmocor system.

Results: Patients, median (range) age 66 (45–86) years exhibited airways obstruction across a wide spectrum of severity. Mean arterial pressure (MAP) was similar in patients and HS, while AIx, APWV, peripheral pulse pressure, and circulating inflammatory mediators were all higher in patients than HS (see table). In patients, APWV was related to age (r = 0.63, p < 0.0001), IL-6 (r = 0.31, p < 0.01), TNFα srI (r = 0.27, p < 0.05), airways obstruction (r = 0.43, p < 0.01) and inversely related to pO2 (r = −0.34, p < 0.01).

AIx APWV (m/s) Pulse pressure (mmHg) IL-6 (pg/ml)
Patients 30.1±8.2 11.4±2.7 62.5±15.9 2.11±1.84
Healthy smokers 25.9±6.2 8.95±1.7 56.5±11.5 1.29±1.58
P value 0.002 p < 0.0001 0.02 p < 0.0001

Conclusions: Aortic stiffness and wave reflections are increased in patients with COPD. Aortic stiffness is related to the severity of airways obstruction, systemic inflammation and hypoxia. This may explain the increased risk of cardiovascular disease in this population.

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Journal
Artery Research
Volume-Issue
1 - S1
Pages
S23 - S23
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70006-6How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - R. Sabit*
AU  - C.E. Bolton
AU  - P.H. Edwards
AU  - I.B. Wilkinson
AU  - J.R. Cockcroft
AU  - D.J. Shale
PY  - 2007
DA  - 2007/06/13
TI  - 02.03 AORTIC STIFFNESS AND WAVE REFLECTIONS ARE INCREASED IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
JO  - Artery Research
SP  - S23
EP  - S23
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70006-6
DO  - 10.1016/S1872-9312(07)70006-6
ID  - Sabit*2007
ER  -