P8.10 THE PATIENTS WITH ISCHEMIC STROKE IN THE POSTERIOR CIRCULATION TERRITORY HAVE IMPAIRED ENDOTHELIAL FUNCTION AND CEREBROVASCULAR REACTIVITY

A.Yu. Vishnyakova; O.B. Kerbikov; S.A. Svoevolin; S.E. Lelyuk; V.G. Lelyuk

doi:10.1016/j.artres.2011.10.131

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Volume 5, Issue 4, December 2011, Pages 185 - 185

P8.10 THE PATIENTS WITH ISCHEMIC STROKE IN THE POSTERIOR CIRCULATION TERRITORY HAVE IMPAIRED ENDOTHELIAL FUNCTION AND CEREBROVASCULAR REACTIVITY

Authors

A.Yu. Vishnyakova¹, O.B. Kerbikov¹, S.A. Svoevolin¹, S.E. Lelyuk², V.G. Lelyuk¹

¹the Russian State Medical University, Moscow, Russian Federation

²the Russian Medical Academy of the Postgraduate Education, Moscow, Russian Federation Impaired endothelial function (EF), cerebrovascular reactivity (CVR) and atherosclerosis can all play a role in the ischemic stroke (IS) pathogenesis

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.131 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

The aim was to assess EF, CVR and intima-media thickness (IMT) in patients with IS in the posterior circulation territory (PCT).

Methods: The study population consisted of 13 patients with IS (without atrial fibrillation) in PCT (72 hours after stroke onset). For these subjects, EF and CVR were compared against an age and gender-matched group consisting of 10 healthy individuals (control group, CG). EF was assessed using the brachial flow-mediated vasodilatation (FMD). Breath-holding test (CVR_BHT=test/baseline mean velocity) and hyperventilation (CVR_HV=baseline/test mean velocity) were used for CVR evaluation in basilar artery (using transcranial Doppler).

Results: We observed a significant difference in FMD between IS patients and CG (5.45±0.9% and 8.97±1.37% respectively, p=0.04). IS patients and CG differed in CVR_BHT (1.25±0.49 and 1.44±0.6 respectively, p=0.04), no difference was detected in CVR_HV (1.5±0.33 and 1.36±0.8 respectively, p>0,05). IMT was similar for IS patients and CG (0.95mm±0.12 and 0.91mm±0.1 respectively, p>0.05). Correlation analysis revealed significant interrelationships between FMD and CVR_BHT (r=0.38); no significant correlations were found between FMD and CVR_HV.

Conclusion: Patients with IS in PST showed impaired EF and CVR (vasodilatation reaction), both being strong indicators of stroke development. The significant correlation between these parameters is a sign that vasodilation of brain arterioles can be at least partially mediated by the endothelium. The absence of any significant differences in IMT is an evidence of equal prevalence of atherosclerosis among general population.

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 185 - 185
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.131 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - A.Yu. Vishnyakova
AU  - O.B. Kerbikov
AU  - S.A. Svoevolin
AU  - S.E. Lelyuk
AU  - V.G. Lelyuk
PY  - 2011
DA  - 2011/11/29
TI  - P8.10 THE PATIENTS WITH ISCHEMIC STROKE IN THE POSTERIOR CIRCULATION TERRITORY HAVE IMPAIRED ENDOTHELIAL FUNCTION AND CEREBROVASCULAR REACTIVITY
JO  - Artery Research
SP  - 185
EP  - 185
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.131
DO  - 10.1016/j.artres.2011.10.131
ID  - Vishnyakova2011
ER  -

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