P9.01 CINACALCET MAY REDUCE ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC RENAL DISEASE AND SECONDARY HYPERPARATHYROIDISM – RESULTS OF A SMALL-SCALE, PROSPECTIVE, OBSERVATIONAL STUDY
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Introduction: Arterial stiffness(AS) is one important cardiovascular risk (CR) in haemodialysis patients. Secondary hyperparathyroidism (SH) is one frequent complication in this patients and become the AS. Cinacalcet is a new drug in the treatment of SH. We proposed to do the next study.
Material and Methods: 21 patients(13 men/8women) with SH were included: age 51,3(18),BMI 25,5(1,3) kgrs/m2. AS was studied with Complior system and determinated pulse wave velocity (PWV), central pressure was determinated with Sphigmocor system, also was calculated ventricular mass (MV) with echocardiography. We determinated different parameters as: Htc, Hb, cholesterol, Alb, Ca, P, PTH, AP and Kt/v, all these were evaluated at the begin and end of study and the pursuit was 12 months and didn’t have changes in the treatment for hypertension. We used t-Student and Spearman’s correlation as statistical method, p<0.05 was considered statistically significative (SS)
Results: The next results were SS between the begin and the end of study: PWV 9,35(1,83) vs 8,66(1,86) p<0.03. VM 166,6(39,4) vs 156(31,8) p<0.06. PTH 1008(846) vs 341(246) p<0.0001, AP 168,5(79,6) vs 124(72,8) p<0.001. PWV had correlations with age r=0,608 p<0.004. PPc r= 0,707 p<0.0001 and VM r=0,405 p<0.07. PTH with AP r=0,542 p<0.014. We didn’t have SS changes with blood pressure and other parameters included in the study.
Conclusions: After one year of treatment with cinacalcet in patients with SH we have observed a significative reduction of PWV and huge tendency of reduction en VM but without changes in blood pressure. Also a significative reduction with PTH and AP.
| Characteristic | Baseline Mean (+/− SE) | After 12 months Mean (+/− SE) | P value |
|---|---|---|---|
| Central systolic BP,mmHg | 127,6(+/− 24.3) | 125,9(+/− 26.4) | ns |
| Peripheral systolic BP, mm Hg | 141.6(+/− 25.0) | 135.1(+/− 26.3) | ns |
| Central diastolic BP,mmHg | 84.7(+/− 13.3) | 79.8(+/− 14.8) | ns |
| Peripheral diastolic BP,mmHg | 83.5(+/− 13.2) | 77.3(+/− 14.8) | 0.051 |
| Central PP, mmHg | 47.4(+/− 16.7) | 46.3(+/− 19.0) | ns |
| Peripheral PP, mmHg | 59.1(+/− 18.3) | 58.1(+/− 20.1) | ns |
| Aortic AIx at HR of 75, % | 31.6(+/− 11.2) | 32.9(+/− 10.5) | ns |
| Aortic PWV, m/s | 9.35(+/− 1.83) | 8.66(+/− 1.86) | 0.030* |
| HR, beats per minute | 75.7(+/− 12.1) | 73.6(+/− 13.3) | ns |
| LV ejection fraction, % | 65.1(+/− 9.0) | 65.8(+/− 6.4) | ns |
| LV interseptal wall Wall thickness, mm | 12.7(+/− 1.9) | 12.5(+/− 1.3) | ns |
| LV mass index, g/m2 | 166.6(+/− 39.4) | 156.1(+/− 31.8) | 0.063 |
| LV posterior wall Thickness, mm | 12.1(+/− 1.7) | 11.9(+/− 1.7) | ns |
Figure 1: AIx= augmentation index; BP= blood pressure; HR= heart rate;
LV= left ventricular, ns= no statistical difference; PP= pulse pressure; PWV=
Pulse wave velocity; SE= standard error. * Statistically significant (p<0.05)
Cite this article
TY - JOUR AU - J. Bonet AU - B. Bayes AU - P. Fernandez-Crespo AU - M. Casals AU - J. Lopez-Ayerbe AU - R. Romero PY - 2011 DA - 2011/11/29 TI - P9.01 CINACALCET MAY REDUCE ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC RENAL DISEASE AND SECONDARY HYPERPARATHYROIDISM – RESULTS OF A SMALL-SCALE, PROSPECTIVE, OBSERVATIONAL STUDY JO - Artery Research SP - 186 EP - 186 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.135 DO - 10.1016/j.artres.2011.10.135 ID - Bonet2011 ER -