Artery Research

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Volume 5, Issue 4, December 2011, Pages 175 - 176

P6.14 WHICH ESTIMATE OF MEAN ARTERIAL PRESSURE IS TO BE USED FOR ADJUSTMENT FOR PULSE WAVE VELOCITY?

Authors
T.K. Soender1, L.M. Van Bortel2, J. Lambrechtsen3, J. Hangaard4, J. Moeller5, K. Egstrup1
1Department of Medical Research, University Hospital of Odense, Svendborg, Denmark
2Heymans Institute of Pharmacology, Gent university, Gent, Belgium
3Department of Cardiology, University Hospital of Odense, Svendborg, Denmark
4Department of Endocrinology, University Hospital of Odense, Svendborg, Denmark
5Department of Cardiology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark Objective: To examine correlation of different estimates of mean arterial pressure (MAP) to pulse wave velocity (PWV) and their effect on statistical adjustment
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.099How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Methods: Patients with hypertension and type-II-DM were included. They were characterized as having controlled (CH), uncontrolled (UH) or resistant hypertension (RH). Patients with UH and RH received intensified antihypertensive treatment for six months.

We measured clinic BP using Omron HEM 757, ABPM rmed using Kivex TM 2430 and Spacelab 90217devices and PWV using Sphygmocor.

Results: We included 108 patients.

MAP measured immediately before measurement of PWV correlated to PWV (R2=0.1, P=0.001 at baseline and R2=0.16, P<0.0001 after six months) whereas ABPM MAP did not (R2=0.01, P=0.31 at baseline and R2=0.01, P=0.25 after six months).

PWV was significantly higher in patients with RH than in patients with CH (P=0.001) but we found no significant reduction in PWV after six months (P=0.16). Reduction in PWV in patients with UH was significant (P=0.02). PWV remained significantly higher in patients with RH (P=0.05) as did reduction in PWV in patients with UH (P=0.05) when including ABPM MAP in the statistical model. However when including clinic MAP, PWV was no longer significantly higher in patients with RH (P=0.08) and reduction in PWV in patients with UH lost significance (P=0.33).

Conclusion: Clinic MAP correlates best with PWV and using clinic MAP for statistical adjustment produces different results from using ABPM MAP. As PWV has a diurnal variation, MAP taken at the same time as PWV is likely the better to correct for.

Variable Baseline After six months
CH (N=33) UH (N=33) RH (N=42) CH UH RH
SBP 122 [118;125] 142 [138;150] 138 [132;147] 126 [117;135] 133 [123;143] 136 [126;143]
PP 52 [45;56] 65 [58;68] 66 [62;70] 55 [43;63] 57 [49;62] 64 [57;70]
PWV 8.3 [7.3;10.6] 9.6 [8.3;11.1] 10.9 [8.4;12.8] 8.8 [7.3;10.1] 8.9 [8;10] 10.3 [8.4;12.8]
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Journal
Artery Research
Volume-Issue
5 - 4
Pages
175 - 176
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.099How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - T.K. Soender
AU  - L.M. Van Bortel
AU  - J. Lambrechtsen
AU  - J. Hangaard
AU  - J. Moeller
AU  - K. Egstrup
PY  - 2011
DA  - 2011/11/29
TI  - P6.14 WHICH ESTIMATE OF MEAN ARTERIAL PRESSURE IS TO BE USED FOR ADJUSTMENT FOR PULSE WAVE VELOCITY?
JO  - Artery Research
SP  - 175
EP  - 176
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.099
DO  - 10.1016/j.artres.2011.10.099
ID  - Soender2011
ER  -