Artery Research

Volume 5, Issue 4, December 2011, Pages 159 - 159

P4.01 STRESS CALCULATIONS IN 3D RECONSTRUCTIONS OF ARTERIES: THE INFLUENCE OF AXIAL IMAGE RESOLUTION

Authors
H.A. Nieuwstadt1, A. Akyildiz1, L. Speelman1, J.J. Wentzel1, R. Virmani2, T. van der Steen1, F. Gijsen1
1Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands
2CVPath Institute Inc., Gaithersburg, United States of America
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.046How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Computational modeling of the stress distribution in vulnerable atherosclerotic plaques facilitates identification of high stress locations which can be related to plaque rupture. The first step in doing 3D biomechanical stress simulations is to accurately re-create the artery geometry from histology or in-vivo imaging. This research investigated the influence of the axial sampling resolution of histology on the stress distribution in plaques.

A 3D reference geometry of a diseased human coronary artery was constructed based on 7 histological images with an axial spacing of 0.5 mm. Three under sampled models were generated: a 3D model based on four slices (1 mm spacing) and two 2D models based on one slice only (Figure 1). The stress distribution was calculated using the Finite Element Method (FEM).

Figure 1

3D geometries (lumen and lipid surfaces shown)

The under sampled 3D model underestimates the peak stress by approximately 3% (Figure 2). The peak stress in the 2D models is 6% higher in one case and 12% lower in the other case. It can be concluded that a lower axial sampling resolution leads to a lower stress estimation due to smoothing of the geometry. Performing 2D simulations results in a more unpredictable stress distribution in that slice. However, approximate stress values and the location of peak stresses can be predicted well with a 3D under sampled geometry, indicating that 1 mm axial sampling might be sufficient for clinical FEM studies.

Figure 2

Von Mises stress distributions.

This research was supported by the Center for Translational Molecular Medicine and the Netherlands Heart Foundation (PARISk)

Journal
Artery Research
Volume-Issue
5 - 4
Pages
159 - 159
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.046How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - H.A. Nieuwstadt
AU  - A. Akyildiz
AU  - L. Speelman
AU  - J.J. Wentzel
AU  - R. Virmani
AU  - T. van der Steen
AU  - F. Gijsen
PY  - 2011
DA  - 2011/11/29
TI  - P4.01 STRESS CALCULATIONS IN 3D RECONSTRUCTIONS OF ARTERIES: THE INFLUENCE OF AXIAL IMAGE RESOLUTION
JO  - Artery Research
SP  - 159
EP  - 159
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.046
DO  - 10.1016/j.artres.2011.10.046
ID  - Nieuwstadt2011
ER  -