P1.04 SYSTOLIC TIME INTERVALS DERIVED FROM CAROTID ARTERY DISTENSION WAVEFORMS FOR INTEGRATED CARDIOVASCULAR RISK ASSESSMENT
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- 10.1016/j.artres.2011.10.010How to use a DOI?
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Background: Circulatory biomechanics dictate that, with given arterial compliance and pulse pressure, left ventricular ejection and isovolumic-contraction durations (Tej and Tic) reflect systolic ventricular function. Cardiovascular risk assessment, therefore, may benefit from accessible and reproducible measurement of these systolic time intervals (STI). We recently developed a tool to extract STI from carotid artery distension waveforms. We used it here to investigate whether systolic ventricular function is different in patients requiring chronic beta-blockade (BB) compared to controls.
Methods and Results: In 81 patients on BB and 87 age- (61±7yrs) and sex-matched untreated controls, we obtained untreated STI and blood pressures. BB patients discontinued medication 1 day prior to measurements. Intra-session coefficients of variation for Tej and Tic were 0.8% and 6.8%; and inter-session 2.7% and 8.4% (i.e. 100%·SDintra/inter/mean).
Tej and pulse pressure (PP), thus the PP·Tej product reflecting ventricular stroke work, were significantly greater in (untreated) BB patients (all p<0.002). Tic was not different between the groups. The Tic/ Tej ratio was smaller for the BB group (p=0.04), indicating increased systolic ventricular function, likely matching the greater stroke work required.
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Conclusions: Patients requiring chronic beta-blockade have longer ventricular ejection periods combined with greater pulse pressures, indicating greater ventricular stroke work and thus enhanced systolic function. Our findings readily demonstrate the accessibility and reproducibility of non-invasive STI measurement in a clinical population.
Cite this article
TY - JOUR AU - K. Reesink AU - P. Boutouyrie AU - P. Brands PY - 2011 DA - 2011/11/29 TI - P1.04 SYSTOLIC TIME INTERVALS DERIVED FROM CAROTID ARTERY DISTENSION WAVEFORMS FOR INTEGRATED CARDIOVASCULAR RISK ASSESSMENT JO - Artery Research SP - 149 EP - 150 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.010 DO - 10.1016/j.artres.2011.10.010 ID - Reesink2011 ER -