Artery Research

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Volume 5, Issue 1, March 2011, Pages 24 - 29

Non-invasive ultrasound-based assessment of ventricular–arterial interaction in vascular Ehlers–Danlos syndrome patients

Authors
Koen D. Reesinka, *, Evelien Hermelinga, Kim-Thanh Ongb, c, Martijn C.G.J. Brouwersd, Robert S. Renemane, Pierre Boutouyrieb, c, Arnold P.G. Hoeksa
aDepartment of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
bUMR872/INSERM, Faculté de Médecine René Descartes, Université Paris-Descartes, Paris, France
cDepartment of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France
dDepartment of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
eDepartment of Physiology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
*Corresponding author. Tel.: +31 (0) 43 3881668. E-mail address: k.reesink@maastrichtuniversity.nl (K.D. Reesink).
Corresponding Author
Koen D. Reesink
Received 22 September 2010, Revised 3 November 2010, Accepted 10 November 2010, Available Online 4 December 2010.
DOI
10.1016/j.artres.2010.11.003How to use a DOI?
Keywords
Arterial rupture; Collagen; Pulse pressure; Radiofrequency; Vascular ultrasound; Ventricular-arterial coupling; Waveform analysis; Systolic time intervals
Abstract

The role of ventricular–arterial hemodynamic interaction in the occurrence of arterial dissection and rupture in vascular Ehlers–Danlos syndrome (vEDS) is unknown. We recently introduced an ultrasound-based method to extract, from common carotid artery (CCA) diameter waveforms, central arterial properties and left ventricular (LV) systolic time intervals. We obtained CCA diameters, compliance and distensibility coefficients, and LV isovolumic contraction and ejection periods (ICP and EP) of 19 vEDS patients (aged 27–65 yrs) and 19 age-matched healthy controls. CCA distension and compliance tended to be lower in vEDS subjects (p = 0.062 and p = 0.073), especially in younger patients. ICP (−12 ms) and EP (−24 ms) were shorter (p < 0.001), while heart rate was increased (+10 bpm; p < 0.001) in vEDS. The ICP/EP ratio and estimated isovolumic dPLV/dt indicated increased LV contractility in vEDS. In conclusion, vascular EDS patients tend to have a lower CCA compliance but a normal pulse pressure, most likely reflecting reduced physical fitness.

Copyright
© 2010 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
5 - 1
Pages
24 - 29
Publication Date
2010/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.11.003How to use a DOI?
Copyright
© 2010 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Koen D. Reesink
AU  - Evelien Hermeling
AU  - Kim-Thanh Ong
AU  - Martijn C.G.J. Brouwers
AU  - Robert S. Reneman
AU  - Pierre Boutouyrie
AU  - Arnold P.G. Hoeks
PY  - 2010
DA  - 2010/12/04
TI  - Non-invasive ultrasound-based assessment of ventricular–arterial interaction in vascular Ehlers–Danlos syndrome patients
JO  - Artery Research
SP  - 24
EP  - 29
VL  - 5
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.11.003
DO  - 10.1016/j.artres.2010.11.003
ID  - Reesink2010
ER  -