8.4 ARTERIAL COMPLIANCE AND CAROTID ATHEROSCLEROSIS IN APOLIPOPROTEIN A-I AMYLOIDOSIS (LEU75PRO)

DOI

10.1016/j.artres.2009.10.176How to use a DOI?

Abstract

Background: Hereditary amyloidosis are late-onset autosomal dominant disorders characterized by amyloid deposition in various tissues. Among them, Apolipoprotein A-I amyloidosis (Leu75Pro) is a rare autosomal dominant condition in which renal, hepatic, and testicular involvement has been demonstrated.No data are available about vascular alterations in this condition.Aim of the study was to evaluate arterial stiffness,assessed by pulse wave velocity (PWV)and carotid artery intima-media thickness (IMT),evaluated by ultrasound, in patients with Apolipoprotein A-I amyloidosis (APO AI). Patients: In 104 patients with APO AI(mean age 52±16 years,56 F) and in 104 subjects matched for age, sex, body mass index (BMI) and blood pressure (BP), PWV and IMT were measured. Results: By definition no differences for age, sex, BMI, BP, heart rate were observed. PWV was significantly higher in patients with APO AI than controls (11.5±2.9 and 10.7±2.3,p< 0.05), even after adjusting for cholesterol, creatinine, mean BP and heart rate measured during PWV assessment. In patients with APO AI the prevalence of increased arterial stiffness (defined as PWV>12m/sec) was significantly greater than in controls (31% vs 17%, p<0.05). Mean common,bifurcation and internal carotid artery IMT were comparable in the two groups(0.87±0.21 vs 0.88±0.17;1.23±0.41 vs 1.25±0.38;0.95±0.33 vs 0.95±0.28 respectively for APO AI vs controls,p=ns). Similar results were obtained for MeanMax IMT and TMax (1.02±0.29 vs 1.03±0.26 and 1.60±0.69 vs 1.56±0.58 p=ns). Conclusion: In patients with Apolipoprotein A-I amyloidosis (Leu75Pro)a significant increase in arterial stiffness is observed,on the contrary carotid artery IMT is comparable to that of matched control subjects.These results may add significant information to the clinical features of this rare genetic disorder.

Open Access

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TY  - JOUR
AU  - A. Paini
AU  - M.L. Muiesan
AU  - M. Salvetti
AU  - C. Aggiusti
AU  - E. Belotti
AU  - C. Agabiti Rosei
AU  - G. Gregorini
AU  - G. Cancarini
AU  - E. Agabiti Rosei
PY  - 2009
DA  - 2009/12/03
TI  - 8.4 ARTERIAL COMPLIANCE AND CAROTID ATHEROSCLEROSIS IN APOLIPOPROTEIN A-I AMYLOIDOSIS (LEU75PRO)
JO  - Artery Research
SP  - 160
EP  - 160
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.176
DO  - 10.1016/j.artres.2009.10.176
ID  - Paini2009
ER  -