P6.12 BRACHIAL ARTERY REACTIVITY IS DIRECTLY PROPORTIONAL TO BASAL BRACHIAL ARTERY TONE: POSSIBLE CONFOUNDER IN MEASURING ENDOTHELIAL FUNCTION

V. Maher; C. Markham; A. OHalloran; M. O’Dowd; M. Carey; A. Brown; D. McInerney

doi:10.1016/j.artres.2009.10.079

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Volume 3, Issue 4, December 2009, Pages 166 - 166

P6.12 BRACHIAL ARTERY REACTIVITY IS DIRECTLY PROPORTIONAL TO BASAL BRACHIAL ARTERY TONE: POSSIBLE CONFOUNDER IN MEASURING ENDOTHELIAL FUNCTION

Authors

V. Maher¹, C. Markham¹, A. OHalloran¹, M. O’Dowd², M. Carey¹, A. Brown², D. McInerney²

¹Dept. of Cardiology, Adelaide Meath Hospital, Tallaght, Dublin, Ireland

²Dept. of Radiology, Adelaide Meath Hospital, Tallaght, Dublin, Ireland

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.079 How to use a DOI?
Abstract: Brachial artery reactivity following compression is used as a surrogate marker of endothelial function. Brachial diameter increases exceeding 10% indicate normal endothelial function. We investigated if basal brachial artery tone influenced brachial artery reactivity.

One hundred never smoking, healthy, normotensive, normolipidaemic subjects (41+9 yrs, 71F, 29M) underwent brachial artery assessments. Basal, Reactive (endothelial dependant diameter change following 4minutes of cuff compression) and Post GTN (endothelial independent dilatation) diameters were recorded.

Tone was calculated as the percent difference in Post GTN and Basal brachial diameters.

Basal diameter 3.6+0.05mm, Reactive diameter 4.0+0.06mm, Post GTN Diameter 4.4+0.1mm

There was a significant correlation between Brachial artery reactivity and basal brachial artery tone (All r=0.60, p<0.0001, Women r=0.57, p<0.0001, Men r=0.68, p<0.0001).

These data indicate that basal brachial tone has a strong association with the degree of brachial artery reactivity in men and women and consideration should be given to the influence of tone on percent reactivity when measuring endothelial function by this methodology.

A Reactivity/Tone ratio should be considered once new cut-off points are determined.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 166 - 166
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.079 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - V. Maher
AU  - C. Markham
AU  - A. OHalloran
AU  - M. O’Dowd
AU  - M. Carey
AU  - A. Brown
AU  - D. McInerney
PY  - 2009
DA  - 2009/12/03
TI  - P6.12 BRACHIAL ARTERY REACTIVITY IS DIRECTLY PROPORTIONAL TO BASAL BRACHIAL ARTERY TONE: POSSIBLE CONFOUNDER IN MEASURING ENDOTHELIAL FUNCTION
JO  - Artery Research
SP  - 166
EP  - 166
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.079
DO  - 10.1016/j.artres.2009.10.079
ID  - Maher2009
ER  -

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