Artery Research

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Volume 3, Issue 4, December 2009, Pages 179 - 179

P2.10 METABOLIC SYNDROME DOES NOT HAVE AN INDEPENDENT IMPACT ON ULTRASOUND INDICES OF PRECLINICAL CARDIOVASCULAR DISEASE

Authors
E. Malshi, C. Morizzo, M. Kozakova, C. Palombo
Department of Internal Medicine, University of Pisa, Pisa, Italy
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.026How to use a DOI?
Abstract

Background: whether metabolic syndrome (MetS) has an independent impact on development of cardiovascular (CV) disease is uncertain.

Aim: to evaluate indices of preclinical CV disease in subjects with MetS.

Methods: we studied 160 subjects: 50 with MetS (ATP III criteria, age 49±12, BMI 36±7, 12 diabetics) and 110 healthy age-matched controls (NL: 59 males, age 47±9, BMI 28±6). Left ventricular (LV) mass and function were assessed by echocardiography, and common carotid artery (CCA) stiffness (b index, pressure-strain elastic modulus EP, and local wave speed WS) by wall tracking (Aloka SSD-5500).

Results: MetS+ showed higher (p<0.01) EP (138±62 vs 110±40 kPa), β(9.5±3.8 vs 8.2±2.3), WS (7±1.5 vs 6±1.1cm/s), cardiac index (3.2±0.7 vs 2.8±0.5 l/min/m2), and LV mass index (LVMI) (102±24 vs 88±21g/m2), and lower peripheral resistance (TPR: 0.016±0.004 vs 0.018±0.004 dyne/s/cm5, p<0.05) than NL. In multivariate analysis (dependent variable WS and independent variables age, sex, SBP, DBP, waist circumference, BMI, triglyceride, HDL-cholesterol and blood glucose levels), the main independent correlated of WS were age and SBP (adjusted r2=0.53, p<0.01), while male gender and waist were predictors of LVM (adjusted r2=0.56, p<0.01).

Conclusions: in subjects without clinical CV disease and various clustering of risk factors, MetS does not seem to represent an independent predictor of preclinical CV involvement. Large artery stiffness appears mainly related to age and BP, and LVM by body size.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
179 - 179
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.026How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - E. Malshi
AU  - C. Morizzo
AU  - M. Kozakova
AU  - C. Palombo
PY  - 2009
DA  - 2009/12/03
TI  - P2.10 METABOLIC SYNDROME DOES NOT HAVE AN INDEPENDENT IMPACT ON ULTRASOUND INDICES OF PRECLINICAL CARDIOVASCULAR DISEASE
JO  - Artery Research
SP  - 179
EP  - 179
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.026
DO  - 10.1016/j.artres.2009.10.026
ID  - Malshi2009
ER  -