Artery Research

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Volume 3, Issue 4, December 2009, Pages 179 - 179

P2.08 INTERRELATIONSHIPS BETWEEN METABOLIC SYNDROME, ERECTILE DYSFUNCTION AND EARLY ATHEROSCLEROSIS

Authors
N. Ioakeimidis, C. Vlachopoulos, G. Antoniou, K. Baou, D. Terentes-Printzios, A. Aggelis, I. Dima, P. Xaplanteris, G. Lazaros, C. Stefanadis
Hippokration General Hospital of Athens, Athens, Greece
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.024How to use a DOI?
Abstract

Purpose: Men with metabolic syndrome (MetS) have an increased prevalence of erectile dysfunction (ED). Large artery stiffness is a marker of vascular wall changes associated with MetS. Aim of the study was to investigate associations between MetS, ED and changes in large artery properties.

Methods: 179 consecutive men with ED were evaluated for penile vascular disease severity by Doppler ultrasonography. Lower Doppler velocities indicate impaired arterial function and vice versa. A mean PSV below 25cm/sec was considered to indicate severe arterial insufficiency (SAI). Large artery stiffness was evaluated with carotid-femoral pulse wave velocity (PWV) using high-fidelity pulse wave analysis.

Results: Patients with SAI (n=56) compared to patients with non arteriogenic ED (PSV>25cm/s, n=123) had increased prevalence of MetS (49 vs.32 % respectively, P<0.05), whereas the 2 groups did not differ regarding age and smoking. Logistic regression analysis for MetS components revealed that blood pressure (OR 7.9, 95%CI, 2.1–30.1, P<0.001) and waist circumference (OR 5.1, 95% CI 1.7– 15.1, P <0.01) were independent determinants of SAI after adjustment for confounders. PWV increased and PSV decreased as the number of MetS components increased (figure).

Conclusions: MetS is strongly associated with increased penile vascular damage and impaired large artery elastic properties. Our findings suggest the presence of a common pathophysiologic pathway and provide a possible marker of risk for cardiovascular disease in men with MetS and ED.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
179 - 179
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.024How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - N. Ioakeimidis
AU  - C. Vlachopoulos
AU  - G. Antoniou
AU  - K. Baou
AU  - D. Terentes-Printzios
AU  - A. Aggelis
AU  - I. Dima
AU  - P. Xaplanteris
AU  - G. Lazaros
AU  - C. Stefanadis
PY  - 2009
DA  - 2009/12/03
TI  - P2.08 INTERRELATIONSHIPS BETWEEN METABOLIC SYNDROME, ERECTILE DYSFUNCTION AND EARLY ATHEROSCLEROSIS
JO  - Artery Research
SP  - 179
EP  - 179
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.024
DO  - 10.1016/j.artres.2009.10.024
ID  - Ioakeimidis2009
ER  -