Artery Research

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Volume 3, Issue 4, December 2009, Pages 171 - 172

P4.07 INFLUENCE OF LONG-ACTING ISOSORBIDE-5-MONONITRATE ADMINISTRATION ON LARGE ARTERIAL STIFFNESS IN PATIENTS WITH ESSENTIAL HYPERTENSION

Authors
F.T. Ageev, E.M. Seredenina, I.A. Orlova, A.G. Plisuk, I.V. Barinova
Cardiology Research Center, Moscow, Russian Federation
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.048How to use a DOI?
Abstract

AIM of this study was to evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (ISMN), in addition to ACE inhibitor on artery stiffness in patients with essential hypertension. MATERIALS AND METHODS. 40 hypertensive patients (mean age 61.3±7.4 years, 9 male, 31 female, mean SBP/DBP=158,1±17,9/91,7±9 mmHg) received moexipril in individual titrated doses (mean dose 11,7±4,8mg daily) for 3 months. 20 patients, which retained SBP>140 and/or DBP>90 mmHg, received additional ISMN (50mg daily) for 4 weeks. Other patients formed the control group. Large arterial stiffness was assessed by automatic noninvasive measurement of the brachial-ankle pulse wave velocity (baPWV). Endothelial function was calculated based on flow-mediated dilatation (FMD) parameters. RESULTS. The 3 months treatment of ACE inhibitor produced a significant reduction in systolic (−26,6 mmHg) and diastolic BP (−10,2 mmHg), baPWV (−1,1m/s) and increase of FMD (+1,5%). Administration with ISMN of 20 pts, without reaching BP target level on treatment of ACE inhibitor, did not to lead to significant decreasing of SBP(−1,3 mmHg), DBP(−2,1mmHg) and baPWV (+0,3m/s). There was no difference in BP and baPWV in ISMN+ACEI treatment group compared with control group (ACEI only). CONCLUSION. Addition of ISMN to ACE inhibitor has no beneficial impact on BP and improvement of arterial stiffness in patient with essential hypertension.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
3 - 4
Pages
171 - 172
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.048How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - F.T. Ageev
AU  - E.M. Seredenina
AU  - I.A. Orlova
AU  - A.G. Plisuk
AU  - I.V. Barinova
PY  - 2009
DA  - 2009/12/03
TI  - P4.07 INFLUENCE OF LONG-ACTING ISOSORBIDE-5-MONONITRATE ADMINISTRATION ON LARGE ARTERIAL STIFFNESS IN PATIENTS WITH ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 171
EP  - 172
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.048
DO  - 10.1016/j.artres.2009.10.048
ID  - Ageev2009
ER  -