Artery Research

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Volume 3, Issue 4, December 2009, Pages 173 - 173

P4.13 REDUCTION OF ARTERIAL STIFFNESS AND CENTRAL BP IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA ON CPAP- THERAPY

Authors
Z.N. Sukmarova, A.Yu. Litvin, A.N. Rogoza, I.E. Chazova
Russian Cardiology Research Complex, Moscow, Russian Federation
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.054How to use a DOI?
Abstract

Arterial stiffness (AS) and central BP (CBP) are new «target-objects» for Antihypertensive Therapy (AT), but the possibility to correction these parameters on nonmedicament treatment is discussed.

Aim: To research the possibilities of correction of AS and CBP by AT and Continuous Positive Airway Pressure (CPAP) in patients (pts) with severe arterial hypertension (AH) and obstructive sleep apnea (OSA) in prospective, randomized, double-blind, placebo- controlled cross- sectional study.

Methods: Included 44 pts (34men) 55,8±9,4 years with AH II-III gr. and OSA index >30, treated with combination of amlodipine 5–10mg, valsartane 160mg and HCT 25mg. After 3–9 week AT pts were randomized into 2 groups: additional effective CPAP (eCPAP) and CPAP-placebo (P=4 mmH2O). After 3 weeks on CPAP-therapy we carried out the crossover of these groups. At each step of intervention we produced ABPM and CBP measuring (SphygmoCor). AS was estimated by Ambulatory AS Index (AASI) and by carotid-to-femoral pulse wave velocity (PWV).

M±STD Initial AT AT+ eCPAP
PWVcf (m/s) 14,3±2,7 12,1±3,2* 11,8±2,2*#
AASI 0,55±0,17 0,48±0,19 ns 0,41±0,18*ns
24hBPmmHg 157/96±21/11 139/86±10/10* 137/81±14/8*#
CBPmmHg 154/99±14/14 129/87±11/9* 122/81±8/7*#
*-

p<0,05#vs initial,

#-

p< 0,05 vs medication.

Results: PWV demonstrated reduction of AS during AT and additional positive effect of eCPAP. Significant reduction of AASI was demonstrated only in cases of combination of AT and CPAP. We estimate additive decreasing of 24h-BP and CBP on eCPAP in comparison CPAP- placebo.

Conclusion: Effective CPAP induced only mild reduction in 24-hBP, but significant decreasing in AS and CBP.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
173 - 173
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.054How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Z.N. Sukmarova
AU  - A.Yu. Litvin
AU  - A.N. Rogoza
AU  - I.E. Chazova
PY  - 2009
DA  - 2009/12/03
TI  - P4.13 REDUCTION OF ARTERIAL STIFFNESS AND CENTRAL BP IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA ON CPAP- THERAPY
JO  - Artery Research
SP  - 173
EP  - 173
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.054
DO  - 10.1016/j.artres.2009.10.054
ID  - Sukmarova2009
ER  -