P5.04 RELATIONSHIP BETWEEN ENDOTHELIAL FUNCTION, INTIMA-MEDIA COMPLEX THICKNESS AND BILIRUBIN LEVELS IN PATIENTS WITH METABOLIC SYNDROME

DOI

10.1016/j.artres.2009.10.059How to use a DOI?

Abstract

Endothelial dysfunction (ED) and carotid artery intima-media complex thickening (IMT) are regarded as predictors for the progress of atherosclerosis. The anti-oxidant properties of bilirubin and its ability to prevent oxidation of lipids of low density lipoproteins, and thus, development of vascular atherosclerosis have also been described.

Our aim was to asses bilirubin levels in patients with metabolic syndrome and various levels of brachial artery flow-mediated dilatation (FMD) registered during reactive hyperaemia test and different carotid artery IMT.

Methods: We examined 181 male subjects, age 31–52 years, with different levels of FMD and IMT, using standard protocol which included physical examination, ECG, carotid arteries ultrasound, brachial arteries ultrasound with reactive hyperaemia test, blood biochemistry tests.

Results: After initial examination patients were divided into two groups in regard to their FMD: 89 patients comprised the group with lower FMD (less then 5%) and 92 subjects who had normal FMD (more then 5%). Performing the ultrasound examination of the carotid arteries we found out that IMT was higher in patients with impaired FMD (p=0.02). On the contrary, in this group we found lower total bilirubin levels comparing to those with normal FMD (8.5±3.2 vs 16.8±4.5 mcmol/l, p<0.01, respectively).

Conclusions: Patients with metabolic syndrome and lower total bilirubin levels present higher IMT and lower FMD and more significant signs of vascular atherosclerosis (as seen in carotid arteries) comparing to those with higher bilirubin levels.

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TY  - JOUR
AU  - O.A. Polikina
AU  - V.V. Vikentyev
PY  - 2009
DA  - 2009/12/03
TI  - P5.04 RELATIONSHIP BETWEEN ENDOTHELIAL FUNCTION, INTIMA-MEDIA COMPLEX THICKNESS AND BILIRUBIN LEVELS IN PATIENTS WITH METABOLIC SYNDROME
JO  - Artery Research
SP  - 174
EP  - 174
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.059
DO  - 10.1016/j.artres.2009.10.059
ID  - Polikina2009
ER  -