Artery Research

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Volume 3, Issue 4, December 2009, Pages 184 - 184

P7.05 ASSOCIATION BETWEEN RENAL FUNCTION AND ARTERIAL STIFFNESS IN NEVER-TREATED HYPERTENSIVES

Authors
D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Aznaouridis, K. Baou, P. Pietri, N. Alexopoulos, I. Dima, A. Siama, C. Stefanadis
1st Department of Cardiology, Athens Medical School, Hippokration General Hospital, Athens, Greece
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.098How to use a DOI?
Abstract

Introduction: Hypertension and renal dysfunction are associated with increased arterial stiffness. Arterial stiffness is a marker of cardiovascular disease and predictor of cardiovascular risk. We assessed the relationship between renal function and arterial stiffness in never-treated hypertensives.

Methods: We enrolled 388 consecutive essential hypertensives (mean age 52±12 years), who had no established cardiovascular disease. Arterial elastic properties were evaluated with carotid-femoral pulse wave velocity (PWV). Renal function was evaluated with blood creatinine and estimated glomerular filtration rate, measured by the simplified Modification of Diet in Renal Disease (MDRD) formula and the Cockcroft-Gault formula.

Results: In multivariable regression analysis PWV significantly correlated with blood creatinine levels (p<0.05, adjusted R2 of model=0.224) and estimated GFR by the Cockroft-Gault formula (p=0.05, adjusted R2 of model=0.222), as well as by the MDRD formula (p<0.05, adjusted R2 of model=0.223). (Figure) The abovementioned correlations were independent of age, sex, body-mass index and mean blood pressure.

Conclusion: This is the first study in never-treated hypertensives that shows a weak but significant relationship between the degree of GFR loss and arterial stiffness, even in individuals with GFR values within the normal renal function range.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
184 - 184
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.098How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D. Terentes-Printzios
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - K. Aznaouridis
AU  - K. Baou
AU  - P. Pietri
AU  - N. Alexopoulos
AU  - I. Dima
AU  - A. Siama
AU  - C. Stefanadis
PY  - 2009
DA  - 2009/12/03
TI  - P7.05 ASSOCIATION BETWEEN RENAL FUNCTION AND ARTERIAL STIFFNESS IN NEVER-TREATED HYPERTENSIVES
JO  - Artery Research
SP  - 184
EP  - 184
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.098
DO  - 10.1016/j.artres.2009.10.098
ID  - Terentes-Printzios2009
ER  -