Artery Research

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Volume 3, Issue 4, December 2009, Pages 172 - 172

P4.10 EFFECT OF SHORT-TERM PERINDOPRIL THERAPY ON ARTERIAL STIFFNESS AND ENDOTHELIAL FUNCTION IN DIASTOLIC HEART FAILURE PATIENTS

Authors
Y. Osmolovskaya1, A. Glechan1, B. Kulev2, A. Skvortsov1, V. Mareev1, S. Tereshenko1
1Russian Cardiology Research and Production Conplex, Heart Failure Department, Moscow, Russian Federation
2Russian Cardiology Research and Production Conplex, Outpatient Department, Moscow, Russian Federation
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.051How to use a DOI?
Abstract

Background: Vascular load is an important determinant of ventricular function. Understanding the physiologic basis of vascular load is central to the development of new strategies and drugs to treat HF. Aim: to evaluate arterial stiffness, endothelial function, clinical status at baseline and in 6 months follow-up period of perindopril therapy in diastolic HF.

Methods: 40 patients with exertional dyspnea, I-II NYHA, EF>45%, aged 62(8,4) years, F/M=27/13, history of CHF 29(16) months, BMI 29,4kg/m2. Arterial stiffness was assessed by measuring carotid-femoral PWV and central: mean BP(MAP), pulse pressure(CPP), AIX using applanation tonometry (Sphygmocor) at the baseline and in 6-months f-up. Endothelial dysfunction using FMD during reactive hyperemia (HDI 5000), clinical status with MQLHF were assessed at the baseline and in 6-months f-up period. All patients were on perindopril therapy, mean dose 8mg/day.

Results:

Baseline 6months f-up p
PWV 10(8,6;11,9) 9(8,3;11,5) =0.06
CSBP 135(123;152) 132(124;140) ns
CDBP 85(79;93) 82(80,5;90) ns
SBP 145(134;154) 131(126;142) <0.05
DBP 85(80;91) 80(76;86) ns
CPP 52(41,5;59) 44(42;52) ns
MAP 105,5(97,5;115,5) 104(98;110) ns
AIX 32,5(27,5;41.5) 38(30,38) ns
FMD 5,6(3;6,5) 6,5(3,3;7,1) <0.05
NYHA FC 2(1;2) 1(1;2) <0.05
MQL 39,5(27;48) 33,5(25;41) ns

Conclusions: The present study demonstrates that short-term perindopril therapy improved endothelial function, led to favourable trends with regard to the reduction of arterial stiffness and resulted in improvement of NYHA functional class in diastolic heart failure patients, that suggests that perindopril is therapeutically usefull in the therapy of diastolic HF.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
172 - 172
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.051How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Y. Osmolovskaya
AU  - A. Glechan
AU  - B. Kulev
AU  - A. Skvortsov
AU  - V. Mareev
AU  - S. Tereshenko
PY  - 2009
DA  - 2009/12/03
TI  - P4.10 EFFECT OF SHORT-TERM PERINDOPRIL THERAPY ON ARTERIAL STIFFNESS AND ENDOTHELIAL FUNCTION IN DIASTOLIC HEART FAILURE PATIENTS
JO  - Artery Research
SP  - 172
EP  - 172
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.051
DO  - 10.1016/j.artres.2009.10.051
ID  - Osmolovskaya2009
ER  -