P3.09 IMPACT OF BIRTH WEIGHT ON BLOOD PRESSURE AND ARTERIAL STIFFNESS

DOI

10.1016/j.artres.2009.10.038How to use a DOI?

Abstract

Objective: Accumulating evidence suggests that low birth weight is associated with increased risk of future cardiovascular risk and increased systolic blood pressure. However the relationship between birth weight and arterial stiffness is controversial. We examined this relationship in the ENIGMA study, a longitudinal study examining the natural history of blood pressure in young adults.

Design and Methods: Data from 882 participants were analysed. The mean age was 21, all were free from cardiovascular disease and medication. Measurements included anthropometric parameters, blood pressure, aortic pulse wave velocity and wave reflections (SphygmoCor) and cardiac output (Innocor). Analyses were conducted in males and females separately, by subdividing into quartiles of birth weight.

Results: There was a positive association between birth weight and adult height in males and females and adult weight and waist circumferences in females. In males lower birth weight was associated with systolic pressure and wave reflections. These associations disappeared after adjustment for height, heart rate and mean pressure.

In females lower birth weight was associated with an increased cardiac output and stroke volume. These associations disappeared when body surface area was taken in to account. There was no association between birth weight and aortic pulse wave velocity.

Conclusion: Our data suggest that the relationship between birth weight and increased augmentation index in healthy, young adults is confounded by other factors such as height and mean pressure. Further studies are required to establish whether low birth weight is associated with an adverse cardiovascular profile in young adults.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - K.L. Miles
AU  - B.J. McDonnell
AU  - J.R. Cockcroft
AU  - I.B. Wilkinson
AU  - C.M. McEniery
PY  - 2009
DA  - 2009/12/03
TI  - P3.09 IMPACT OF BIRTH WEIGHT ON BLOOD PRESSURE AND ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 182
EP  - 182
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.038
DO  - 10.1016/j.artres.2009.10.038
ID  - Miles2009
ER  -