P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE

R. DeBasso; B. Hedblad; J. Carlson; G. Berglund; T. Länne

doi:10.1016/j.artres.2009.10.040

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Volume 3, Issue 4, December 2009, Pages 183 - 183

P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE

Authors

R. DeBasso¹, B. Hedblad², J. Carlson³, G. Berglund⁴, T. Länne⁵

¹Department of Clinical Physiology, Jönköping Hospital, Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Jönköping, Linköping, Sweden

²Department of Clinical Sciences, Epidemiological Research Group, University Hospital Malmö, Lund University, Malmö, Sweden

³Department of Clinical Chemistry, University Hospital Malmö, Lund University, Lund, Sweden

⁴Department of Clinical Sciences, Internal Medicine Research Group, University Hospital Malmö, Lund University, Malmö, Sweden

⁵Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.040 How to use a DOI?
Abstract: Background: Fibrillin-1 is an important constituent of the vascular wall and earlier studies have indicated an effect of the fibrillin-1 2–3 genotype on blood pressure as well as aortic stiffness. The aim was to determine if the Fibrillin-1 2–3 genotype is associated with increased cardiovascular morbidity/mortality in middle-aged individuals.

Method: The fibrillin-1 genotype was characterized by PCR in 5765 individuals (2424 men, 3341 women 45–69 yrs) recruited from the Cardiovascular Cohort in Malmö Diet and Cancer-study. The intima media thickness (IMT) of the common carotid artery (CCA) was visualised by B-mode ultrasound. The follow up on the number of cardiovascular events (myocardial infarction and stroke) as well as all cause mortality was monitored during 1991 to 2001.

Results: The most common genotypes were 2–2, 2–3 and 2–4 which accounted for 92.2% (n=5317) of the individuals. There were no differences between the three genotypes regarding age, blood pressures, smoking, glucose, lipids, CCA diameter and IMT.

Regarding the occurrence of plaque in the CCA the men with the 2–3 genotype had more plaque than the 2–2 and 2–4 genotypes, (54% vs 46% and 50%, p=.007). The follow up (mean 8.55 yrs) of cardiovascular events and mortality did however not differ between the genotypes.

Conclusions: The increased plaque occurrence in the carotid artery of middle-aged men with fibrillin-1 2–3 genotype indicates a pathologic arterial wall remodelling with a more pronounced atherosclerotic burden. The effect of the 2–3 genotype on cardiovascular events and mortality seems however to be minor.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 183 - 183
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.040 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - R. DeBasso
AU  - B. Hedblad
AU  - J. Carlson
AU  - G. Berglund
AU  - T. Länne
PY  - 2009
DA  - 2009/12/03
TI  - P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE
JO  - Artery Research
SP  - 183
EP  - 183
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.040
DO  - 10.1016/j.artres.2009.10.040
ID  - DeBasso2009
ER  -

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