P8.10 THE RELATIONSHIP BETWEEN AUGMENTATION INDEX AND AGEING: A META-REGRESSION ANALYSIS

DOI

10.1016/j.artres.2009.10.116How to use a DOI?

Abstract

It has been reported that augmentation index (AI_x) increases with age, but that the increase is more prominent in younger subjects [1], and may even decrease with age in individuals over 50yrs [2]. We undertook a meta-analysis of the published literature of 9,551 individuals (5,659 male), aged 4 to 91 years (mean 54.2 years) and undertook meta-regression to further investigate the relationship of AI_x with age. AI_x increased with age (0.51 (0.41, 0.61) %/yr; coefficient (95% CI); adjusted r²=59.97%; p<0.0001) with little evidence of marked non-linearity over the life course (Figure).

Meta-analysis of AI_x vs age (solid line) with LOWESS fit shown(dashed line).

This meta-analysis suggests that AI_x increases relatively uniformly with age, although there may be a small decline in the rate of increase at older ages.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - A.J. Baksi
AU  - T.A. Treibel
AU  - J.E. Davies
AU  - N. Hadjiloizou
AU  - R.A. Foale
AU  - K.H. Parker
AU  - D.P. Francis
AU  - J. Mayet
AU  - A.D. Hughes
PY  - 2009
DA  - 2009/12/03
TI  - P8.10 THE RELATIONSHIP BETWEEN AUGMENTATION INDEX AND AGEING: A META-REGRESSION ANALYSIS
JO  - Artery Research
SP  - 189
EP  - 189
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.116
DO  - 10.1016/j.artres.2009.10.116
ID  - Baksi2009
ER  -