Artery Research

Volume 1, Issue 2, September 2007, Pages 76 - 76

P.101PULSATILE ARTERIAL PRESSURE IS PREDOMINANTLY DETERMINED BY THE CENTRAL RESERVOIR, WHICH CAN BE DETERMINED NON-INVASIVELY FROM PERIPHERAL MEASUREMENT SITES

Authors
J.E. Davies1, A. Malaweera1, N. Hadjiloizou1, K.H. Parker2, J. Aguado-Sierra2, J. Mayet1, D.P. Francis1, A.D. Hughes1
1International Centrel for Circulatory Health, Imperial College & St Mary's Hospital, London, United Kingdom
2Physiological Flow Unit, Department of Bioengineering, Imperial College, London, United Kingdom
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: There is a large variation in the pulse pressure waveform in systole throughout the arterial system. However, at these corresponding sites, the diastolic phase appears almost identical. We hypothesise that this is because diastolic pressure is predominately determined by the reservoir properties of the central elastic arteries, despite large differences in wave reflection and local compliance of peripheral arteries themselves. We assessed the contribution of the central reservoir to the peripheral pulse pressure waveform.

Method and Results: Pressure and flow velocity were measured non-invasively at right common carotid and radial arteries in 14 healthy volunteers (49±11 years) using tonometry, calibrated to brachial blood pressure, and Doppler ultrasound. We calculated the reservoir pressure and compliance (local pulse wave velocity). The time constant of diastolic decay (τ) was calculated from the exponential rate of decline in pressure during diastole. Reservoir pressure was the largest overall contributor to pulse pressure in the carotid (28.0±4.8mmHg; 53±6%), and radial (32.0±6.2mmHg; 48±4%). τ was similar in each artery (carotid: 427±281ms versus radial: 427±320ms (p>0.99) despite large differences in local pulse wave velocity (carotid: 7.2±2.6ms−1 versus radial: 10.9±5.0ms−1, p<0.05).

Conclusion: The reservoir is the largest determinant of pulse pressure and is similar in central and peripheral arterial sites, despite significant variation in local compliance. Estimation of reservoir pressure in the radial artery may be a simple and useful indicator of the properties of the aorta and large elastic arteries.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
76 - 76
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.E. Davies
AU  - A. Malaweera
AU  - N. Hadjiloizou
AU  - K.H. Parker
AU  - J. Aguado-Sierra
AU  - J. Mayet
AU  - D.P. Francis
AU  - A.D. Hughes
PY  - 2007
DA  - 2007/08/30
TI  - P.101PULSATILE ARTERIAL PRESSURE IS PREDOMINANTLY DETERMINED BY THE CENTRAL RESERVOIR, WHICH CAN BE DETERMINED NON-INVASIVELY FROM PERIPHERAL MEASUREMENT SITES
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.035
DO  - 10.1016/j.artres.2007.07.035
ID  - Davies2007
ER  -