Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

Justin E. Davies; Nearchos Hadjiloizou; Debora Leibovich; Anura Malaweera; Jordi Alastruey-Arimon; Zachary I. Whinnett; Charlotte H. Manisty; Darrel P. Francis; Jazmin Aguado-Sierra; Rodney A. Foale; Iqbal S. Malik; Kim H. Parker; Jamil Mayet; Alun D. Hughes

doi:10.1016/j.artres.2007.08.001

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Volume 1, Issue 2, September 2007, Pages 40 - 45

Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

Authors

Justin E. Davies^a^{, *}, Nearchos Hadjiloizou^a, Debora Leibovich^b, Anura Malaweera^a, Jordi Alastruey-Arimon^b, Zachary I. Whinnett^a, Charlotte H. Manisty^a, Darrel P. Francis^a, Jazmin Aguado-Sierra^b, Rodney A. Foale^a, Iqbal S. Malik^a, Kim H. Parker^b, Jamil Mayet^a, Alun D. Hughes^a

^aInternational Centre for Circulatory Health, St Mary’s Hospital and Imperial College, 59-61 North Wharf Road, Paddington, London W2 1LA, UK

^bPhysiological Flow Unit, Department of Bioengineering, Imperial College, London, UK

^*Corresponding author. Tel.: +44 207 5941093; fax: +44 207 5941388. E-mail address: wave-reservoir@heart123.com (J.E. Davies).

Corresponding Author

Justin E. Davies

Available Online 30 August 2007.

DOI: 10.1016/j.artres.2007.08.001 How to use a DOI?
Keywords: Aortic pressure; Wave reflection; Windkessel; Aortic cushioning; Augmentation index
Abstract: It has been recognised for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir–wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.
Copyright: © 2007 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 1 - 2
Pages: 40 - 45
Publication Date: 2007/08/30
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2007.08.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Justin E. Davies
AU  - Nearchos Hadjiloizou
AU  - Debora Leibovich
AU  - Anura Malaweera
AU  - Jordi Alastruey-Arimon
AU  - Zachary I. Whinnett
AU  - Charlotte H. Manisty
AU  - Darrel P. Francis
AU  - Jazmin Aguado-Sierra
AU  - Rodney A. Foale
AU  - Iqbal S. Malik
AU  - Kim H. Parker
AU  - Jamil Mayet
AU  - Alun D. Hughes
PY  - 2007
DA  - 2007/08/30
TI  - Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank
JO  - Artery Research
SP  - 40
EP  - 45
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.08.001
DO  - 10.1016/j.artres.2007.08.001
ID  - Davies2007
ER  -

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