Performance assessment of pulse wave imaging using conventional ultrasound in canine aortas ex vivo and normal human arteries in vivo

Ronny X. Li; William Qaqish; Elisa E. Konofagou

doi:10.1016/j.artres.2015.06.001

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Volume 11, Issue C, September 2015, Pages 19 - 28

Performance assessment of pulse wave imaging using conventional ultrasound in canine aortas ex vivo and normal human arteries in vivo

Authors

Ronny X. Li^a, William Qaqish^a, Elisa E. Konofagou^a^{, b}^{, *}

^aUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA

^bDepartment of Radiology, Columbia University, New York, NY, USA

^*Corresponding author. 630 West 168th Street, Physicians & Surgeons 19-418, New York, NY 10032, USA. Tel.: +1 212 342 0863; fax: +1 212 342 1648. E-mail address: ek2191@columbia.edu (E.E. Konofagou).

Corresponding Author

Elisa E. Konofagou

Received 21 May 2015, Accepted 11 June 2015, Available Online 22 July 2015.

DOI: 10.1016/j.artres.2015.06.001 How to use a DOI?
Keywords: Abdominal aorta; Arterial stiffness; Carotid artery; Pulse wave; Pulse wave velocity (PWV); Pulse wave imaging (PWI); Speckle tracking; Ultrasound
Abstract: The propagation behavior of the arterial pulse wave may provide valuable diagnostic information for cardiovascular pathology. pulse wave imaging (PWI) is a noninvasive, ultrasound imaging-based technique capable of mapping multiple wall motion waveforms along a short arterial segment over a single cardiac cycle, allowing for the regional pulse wave velocity (PWV) and propagation uniformity to be evaluated. The purpose of this study was to improve the clinical utility of PWI using a conventional ultrasound system. The tradeoff between PWI spatial and temporal resolution was evaluated using an ex vivo canine aorta (n = 2) setup to assess the effects of varying image acquisition and signal processing parameters on the measurement of the PWV and the pulse wave propagation uniformity r². PWI was also performed on the carotid arteries and abdominal aortas of 10 healthy volunteers (24.8 ± 3.3 y.o.) to determine the waveform tracking feature that would yield the most precise PWV measurements and highest r² values in vivo. The ex vivo results indicated that the highest precision for measuring PWVs ~2.5–3.5 m/s was achieved using 24–48 scan lines within a 38 mm image plane width (i.e. 0.63–1.26 lines/mm). The in vivo results indicated that tracking the 50% upstroke of the waveform would consistently yield the most precise PWV measurements and minimize the error in the propagation uniformity measurement. Such findings may help establish the optimal image acquisition and signal processing parameters that may improve the reliability of PWI as a clinical measurement tool.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 11 - C
Pages: 19 - 28
Publication Date: 2015/07/22
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.06.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Ronny X. Li
AU  - William Qaqish
AU  - Elisa E. Konofagou
PY  - 2015
DA  - 2015/07/22
TI  - Performance assessment of pulse wave imaging using conventional ultrasound in canine aortas ex vivo and normal human arteries in vivo
JO  - Artery Research
SP  - 19
EP  - 28
VL  - 11
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.06.001
DO  - 10.1016/j.artres.2015.06.001
ID  - Li2015
ER  -

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