Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa

Birinus Ezeala-Adikaibe; Yan-Ping Liu; Daniel Lemogoum; Benedict C. Anisiuba; Marius K. Kamdem; Joseph Kaptue; Chinwuba K. Ijoma; Lutgarde Thijs; Augustine N. Odili; Kei Asayama; Jan A. Staessen; Jean-René M’Buyamba-Kabangu; Ifeoma I. Ulasi

doi:10.1016/j.artres.2011.11.002

<Previous Article In Issue

Next Article In Issue>

Volume 6, Issue 1, March 2012, Pages 41 - 48

Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa

Authors

Birinus Ezeala-Adikaibe^a^{, b}^{, g}, Yan-Ping Liu^b^{, g}, Daniel Lemogoum^c^{, g}, Benedict C. Anisiuba^a^{, g}, Marius K. Kamdem^c^{, g}, Joseph Kaptue^c^{, g}, Chinwuba K. Ijoma^a^{, g}, Lutgarde Thijs^b^{, g}, Augustine N. Odili^b^{, d}^{, g}, Kei Asayama^b^{, g}, Jan A. Staessen^b^{, e}^{, *}^{, g}, Jean-René M’Buyamba-Kabangu^f^{, g}, Ifeoma I. Ulasi^a^{, g}

^aDepartment of Medicine, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria

^bStudies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE-3000 Leuven, Belgium

^cDepartment of Internal Medicine, College of Health Science, University of Abuja, Abuja, Nigeria

^dDouala Cardiovascular Research Institute, Douala School of Medicine, Douala, Cameroon

^eDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands

^fHypertension Unit, Department of Internal Medicine, University of Kinshasa Hospital, Kinshasa, The Democratic Republic of the Congo

^g

On behalf of the NOAAH investigators.

^*Corresponding author. Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block D, Box 7001, BE-3000 Leuven, Belgium. Tel.: +32 16 347104, +32 15 41 1747 (home), +32 47 632 4928 (mobile); fax: +32 16 347106 (office), +32 15 41 4542 (home). E-mail addresses: jan.staessen@med.kuleuven.be, ja.staessen@epid.unimaas.nl (J.A. Staessen).

Corresponding Author

Jan A. Staessen

Received 12 October 2011, Revised 21 November 2011, Accepted 23 November 2011, Available Online 14 December 2011.

DOI: 10.1016/j.artres.2011.11.002 How to use a DOI?
Keywords: Arterial stiffness; Augmentation index; Black Africans; Prevention; Pulse wave velocity
Abstract: Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions.

Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting native African patients to compare the efficacy of various antihypertensive drugs given once daily as single-pill combinations. Two centres engaged in pulse wave analysis and measured carotid–femoral pulse wave velocity (PWV). Statistical methods included single and multiple linear regressions.

Results: Of 172 patients screened, 116 entered the ancillary study on central haemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1mmHg). The augmentation indexes were higher (p<0.0001) in women than men, both peripherally (pAI, 11.1 vs. −10.6%) and centrally (cAI, 39.0 vs. 28.0%). PWV (8.91m/s) and central pulse pressure (cPP, 48.7mmHg) were similar (p>0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV.

Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations highlight the potential for the prevention of irreversible arterial damage by timely treating sub-Saharan hypertensive patients to target blood pressure levels.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 6 - 1
Pages: 41 - 48
Publication Date: 2011/12/14
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.11.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Birinus Ezeala-Adikaibe
AU  - Yan-Ping Liu
AU  - Daniel Lemogoum
AU  - Benedict C. Anisiuba
AU  - Marius K. Kamdem
AU  - Joseph Kaptue
AU  - Chinwuba K. Ijoma
AU  - Lutgarde Thijs
AU  - Augustine N. Odili
AU  - Kei Asayama
AU  - Jan A. Staessen
AU  - Jean-René M’Buyamba-Kabangu
AU  - Ifeoma I. Ulasi
PY  - 2011
DA  - 2011/12/14
TI  - Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa
JO  - Artery Research
SP  - 41
EP  - 48
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.11.002
DO  - 10.1016/j.artres.2011.11.002
ID  - Ezeala-Adikaibe2011
ER  -

download .riscopy to clipboard