Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index
- DOI
- 10.1016/j.artres.2011.08.003How to use a DOI?
- Keywords
- Pulse wave velocity; Arterial stiffness; Vascular disease; Atherosclerosis; Ankle–brachial index
- Abstract
Background: Central Pulse Wave Velocity (PWV) is considered to be the gold standard measurement of arterial stiffness. In healthy subjects, cardiovascular risk factors such as age, hypertension, diabetes and end-stage renal disease are associated with increased central (Carotid–Femoral) and peripheral (Femoral–Ankle) PWV. However, little is known about PWV in patients with peripheral arterial disease and pathological Ankle–Brachial Index (ABI). The aim of this study was to study central and peripheral PWV in a population with various degree of peripheral arterial disease.
Methods: Central and peripheral PWV were measured in sixty-two hospitalized patients. Half were admitted for symptomatic peripheral vascular disease and the remainder for cardiac or carotid disease. The population was classified on basis of the Framingham-derived risk score for claudicants and on the ABI. For all patients, PWV was assessed on electrocardiogram-ultrasonographic images acquired at the four following sites: carotid, radial, femoral and tibial arteries.
Results: Carotid–Femoral PWV increased significantly with the Framingham-derived global risk score (p < 0.0001) but Femoral–Ankle PWV did not. With respect to the Ankle–Brachial Index, Carotid–Femoral and Femoral–Ankle PWV significantly increased (p = 0.05 and p = 0.02 respectively) with the severity of peripheral arterial scoring.
Conclusions: These results confirm that central PWV is the best indicator of general atherosclerosis, even in the presence of peripheral arterial disease. Both central and peripheral PWV can be considered as indicators of the severity of peripheral vascular disease.
- Copyright
- © 2011 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
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TY - JOUR AU - Valérie Lacroix AU - Marie Willemet AU - Robert Verhelst AU - Christophe Beauloye AU - Luc Jacquet AU - Parla Astarci AU - Alexandre Persu AU - Emilie Marchandise PY - 2011 DA - 2011/09/09 TI - Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index JO - Artery Research SP - 28 EP - 33 VL - 6 IS - 1 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.08.003 DO - 10.1016/j.artres.2011.08.003 ID - Lacroix2011 ER -