Structural proteins and arterial ageing

DOI

10.1016/j.artres.2012.12.001How to use a DOI?

Keywords

Arteriosclerosis; Elasticity; Atomic force microscopy; Nanoindentation; Oxidative damage

Abstract

In common with most dynamic tissues, the mechanical properties of arteries are determined by the relative composition and architecture of key structural extracellular matrix (ECM) proteins including fibrillar collagens and elastic fibre components. Although it is apparent that age-related loss of ECM homeostasis leads to arteriosclerosis (vascular stiffening), which in turn is associated with the development of both fatal strokes and heart failure, the principal molecular targets and causative mechanisms remain poorly defined. This review discusses: (i) the application of in situ micro-mechanical methodologies to localise the key molecular targets of age-related stiffening within arteries and other dynamic elastic tissues and (ii) the potential role played by the preferential oxidation of TGF-β binding elastic fibre-associated components in driving this aberrant tissue remodelling.

Copyright

© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

Open Access

This is an open access article distributed under the CC BY-NC license.

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TY  - JOUR
AU  - Michael J. Sherratt
PY  - 2012
DA  - 2012/12/29
TI  - Structural proteins and arterial ageing
JO  - Artery Research
SP  - 15
EP  - 21
VL  - 7
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.12.001
DO  - 10.1016/j.artres.2012.12.001
ID  - Sherratt2012
ER  -