Vascular smooth muscle cell phenotypic modulation and the extracellular matrix

Maryam Heidari; Craig A. Mandato; Stephanie Lehoux

doi:10.1016/j.artres.2014.12.002

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Volume 9, Issue C, March 2015, Pages 14 - 18

Vascular smooth muscle cell phenotypic modulation and the extracellular matrix

Authors

Maryam Heidari^a, Craig A. Mandato^a, Stephanie Lehoux^b^{, *}

^aDepartment of Anatomy & Cell Biology, Faculty of Medicine, McGill University, Montreal, QC, Canada H3A 2B2

^bLady Davis Institute for Medical Research, Faculty of Medicine, McGill University, Montreal, QC, Canada H3T 1E2

^*Corresponding author: Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, QC, Canada H3T 1E2. Tel.: +1 514 340 8222. E-mail address: stephanie.lehoux@mcgill.ca (S. Lehoux).

Corresponding Author

Stephanie Lehoux

Received 21 December 2011, Revised 6 June 2014, Accepted 15 December 2014, Available Online 3 January 2015.

DOI: 10.1016/j.artres.2014.12.002 How to use a DOI?
Keywords: Restenosis; Neointima; Extracellular matrix; Remodeling
Abstract: Intervascular stents provide clinical benefits in preventing occlusive coronary artery disease after angioplasty, but intimal hyperplasia and restenosis after stent implantation remains an unresolved problem. Vascular smooth muscle cells (VSMCs), the main component of medial layer of arteries, play an important role in neointimal hyperplasia. After arterial injury, quiescent, contractile VSMCs undergo a change in phenotype; they proliferate and migrate from the media to the intima. It has been shown that the extracellular matrix (ECM) plays a key role in tissue formation, homeostasis and repair. The adhesion, proliferation, and migration of VSMCs are strongly influenced by interaction with ECM components including proteoglycans, glycoproteins such as fibronectin, collagen, elastic fibers (laminae). This interaction is further diversified under the influence of multiple transmembrane receptors and matrix proteinases. Hence, the coordinated regulation of VSMC function by these matrix components is an essential process for controlling the development and remodeling of the vascular system. Here the role of ECM in VSMC phenotypic modulation and neointimal hyperplasia will be reviewed.
Copyright: © 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 9 - C
Pages: 14 - 18
Publication Date: 2015/01/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.12.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Maryam Heidari
AU  - Craig A. Mandato
AU  - Stephanie Lehoux
PY  - 2015
DA  - 2015/01/03
TI  - Vascular smooth muscle cell phenotypic modulation and the extracellular matrix
JO  - Artery Research
SP  - 14
EP  - 18
VL  - 9
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.12.002
DO  - 10.1016/j.artres.2014.12.002
ID  - Heidari2015
ER  -

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