Artery Research

Volume 25, Issue 1-2, June 2019, Pages 65 - 69

Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients

Authors
Jun Xu, Feng-Feng Pan, Chan-Chan Xu, Yuan Zhong, Ting-Jun Hu, Guo-Xiang Fu*
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yi Shan Road, Shanghai, P R China
*Corresponding author. Email: fuguoxiang888@163.com
Corresponding Author
Guo-Xiang Fu
Received 21 November 2019, Accepted 24 November 2019, Available Online 4 December 2019.
DOI
10.2991/artres.k.191125.001How to use a DOI?
Keywords
Arterial stiffness; cathepsin L; geriatric patients
Abstract

Background: Cathepsin L (Cat L) is involved in the regulation of vascular aging processes. The aim of this study was to evaluate the relationship between plasma Cat L level and arterial stiffness marker through brachial-ankle pulse wave velocity (baPWV) in geriatric patients.

Methods: Cross-sectional study with 502 people were selected from a population of 2250 people aged over 65 years old, from three different basic health zones of Shanghai. Blood samples were collected, and the baPWV was measured with the SphygmoCor system. The geriatric patients with baPWV values >20 m/s were defined as the high arterial stiffness group.

Results: In total, 248 (49.4%) of the 502 geriatric patients in this study were in the high arterial stiffness group. The high arterial stiffness group were older (p = 0.006) and had higher prevalence of hypertension (p = 0.020), coronary heart disease (CHD) (p = 0.037), higher systolic blood pressure (SBP) (p = 0.018), pulse pressure (p = 0.017), plasma Cat L (p = 0.002) and logarithmically transformed C-reactive protein (p = 0.023) levels than those in the low arterial stiffness group. Multivariable forward stepwise regression analysis showed that Cat L (β = 0.418, p = 0.011) and hypertension (β = 0.217, p = 0.029) were associated with baPWV values in geriatric patients. Moreover, an increased plasma Cat L level (odds ratio (OR): 1.048; 95% confidence interval (CI): 1.043–1.169; p = 0.018) was an independent factor for arterial stiffness among the geriatric patients.

Conclusion: In this study, plasma Cat L level was positively correlated with arterial stiffness in geriatric patients.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - 1-2
Pages
65 - 69
Publication Date
2019/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191125.001How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Jun Xu
AU  - Feng-Feng Pan
AU  - Chan-Chan Xu
AU  - Yuan Zhong
AU  - Ting-Jun Hu
AU  - Guo-Xiang Fu
PY  - 2019
DA  - 2019/12/04
TI  - Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients
JO  - Artery Research
SP  - 65
EP  - 69
VL  - 25
IS  - 1-2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191125.001
DO  - 10.2991/artres.k.191125.001
ID  - Xu2019
ER  -