Artery Research

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Volume 21, Issue C, March 2018, Pages 38 - 42

Vasoreactivity of thoracic aorta in Nigella Sativa supplemented and/or exercise trained rats

Authors
Rabia Latif*, Al-Asoom LI
Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
*Corresponding author. E-mail address: rlhussain@uod.edu.sa (R. Latif).
Corresponding Author
Rabia Latif
Received 22 October 2017, Revised 18 December 2017, Accepted 24 December 2017, Available Online 11 January 2018.
DOI
10.1016/j.artres.2017.12.006How to use a DOI?
Keywords
Nigella sativa; Exercise; Vascular sensitivity; Thoracic aorta
Abstract

Background: Nigella Sativa (NS) induced vasorelaxation of aortic rings upon direct exposure has been documented in literature. This study was conducted to determine whether 8 weeks Nigella Sativa supplementation and/or exercise training may alter vascular sensitivity of rat aorta in normal, healthy rats.

Methods: In this Quasi Experimental Study, forty adult male Wistar albino rats were divided equally into 4 groups. One group served as the control (C), whereas the other three groups were Nigella-treated (N; 800 mg/kg Nigella daily orally via a feeding needle), Exercise-trained (Ex: 18 m/min speed, 2 h duration/day at 32 inclination) and Nigella-treated-exercise-trained (N-Ex: received both Nigella and exercise training). After 8 weeks, rats in all four groups were sacrificed. Their aortic rings were2 mounted in the organ bath. Tension in the aortic rings was measured with an isometric force transducer and recorded with a PowerLab data-acquisition system. Norepinephrine-induced aortic contractions in all four groups were compared by one-way analysis of variance (ANOVA).

Results: There were statistically insignificant differences in Norepinephrine-induced aortic contractions among all four groups (P value 0.26, 0.18, 0.07, 0.12, 0.58, 0.24, 0.06 with Norepinephrine 0, 10−7, 10−6, 10−5, 10−4, 10−3, 10−2 respectively). Also, no statistical difference was observed in term of body weight, heart weight, left ventricular weight and their indices in all four groups.

Conclusion: NS supplementation and exercise training alone or in combination; for 8 weeks’ duration, may not alter vascular reactivity in normal healthy rats.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
21 - C
Pages
38 - 42
Publication Date
2018/01/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.12.006How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rabia Latif
AU  - Al-Asoom LI
PY  - 2018
DA  - 2018/01/11
TI  - Vasoreactivity of thoracic aorta in Nigella Sativa supplemented and/or exercise trained rats
JO  - Artery Research
SP  - 38
EP  - 42
VL  - 21
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.12.006
DO  - 10.1016/j.artres.2017.12.006
ID  - Latif2018
ER  -