Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men

Kaname Tagawa; Song-Gyu Ra; Hiroshi Kumagai; Yuriko Sawano; Kosaku Yamamoto; Toru Yoshikawa; Youngju Choi; Yasuko Yoshida; Kazuhiro Takekoshi; Seiji Maeda

doi:10.1016/j.artres.2018.08.001

<Previous Article In Issue

Volume 23, Issue C, September 2018, Pages 63 - 70

Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B₂ concentrations in young men

Authors

Kaname Tagawa^a, Song-Gyu Ra^b, Hiroshi Kumagai^c, Yuriko Sawano^a, Kosaku Yamamoto^a, Toru Yoshikawa^a, Youngju Choi^d, Yasuko Yoshida^a, Kazuhiro Takekoshi^e, Seiji Maeda^d^{, *}

^aGraduate School of Comprehensive Human Sciences, University of Tsukuba, Japan

^bFaculty of Sports and Health Science, Fukuoka University, Japan

^cFaculty of Health and Sports Science, Juntendo University, Japan

^dFaculty of Health and Sport Sciences, University of Tsukuba, Japan

^eFaculty of Medicine, University of Tsukuba, Japan

^*Corresponding author. Division of Sports Medicine, Faculty of Health and Sport Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan. Fax: +81 29 853 2986. E-mail address: maeda.seiji.gn@u.tsukuba.ac.jp (S. Maeda).

Corresponding Author

Seiji Maeda

Received 22 February 2018, Revised 12 July 2018, Accepted 14 August 2018, Available Online 18 September 2018.

DOI: 10.1016/j.artres.2018.08.001 How to use a DOI?
Keywords: Resistance training; Carotid arterial compliance; Vasoconstrictive mediator; Platelet aggregation; Young men
Abstract: Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training. The thromboxane has both potent vasoconstrictive and platelet aggregation effects, and is associated with cardiovascular diseases. However, whether thromboxane is involved in resistance training-induced decrease in central arterial compliance is unclear. The present study aimed to investigate relationships between circulating thromboxane levels and central arterial compliance in both cross-sectional and longitudinal (i.e., resistance training) designs.

Methods and results: First, in a cross-sectional study, we assessed association between circulating thromboxane concentrations and central arterial compliance in 63 young men, who showed significant negative correlation between those parameters. Second, in a longitudinal study, we examined effects of high-intensity resistance training on circulating thromboxane concentrations and central arterial compliance and relationship among changes from baseline in those parameters. Young sedentary men were assigned to control (n = 7) or training (n = 17) groups. Subjects in training group underwent four-week supervised high-intensity resistance training. Resistance training significantly elevated circulating thromboxane concentrations and decreased central arterial compliance; no significant change was observed in control group, and there was significant correlation between changes in those parameters.

Conclusions: circulating thromboxane is possible mechanism explaining resistance training-induced decrease in central arterial compliance in young men.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 23 - C
Pages: 63 - 70
Publication Date: 2018/09/18
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.08.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Kaname Tagawa
AU  - Song-Gyu Ra
AU  - Hiroshi Kumagai
AU  - Yuriko Sawano
AU  - Kosaku Yamamoto
AU  - Toru Yoshikawa
AU  - Youngju Choi
AU  - Yasuko Yoshida
AU  - Kazuhiro Takekoshi
AU  - Seiji Maeda
PY  - 2018
DA  - 2018/09/18
TI  - Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men
JO  - Artery Research
SP  - 63
EP  - 70
VL  - 23
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.08.001
DO  - 10.1016/j.artres.2018.08.001
ID  - Tagawa2018
ER  -

download .riscopy to clipboard