P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis

Nadège Côté; Emy Philibert; Mathilde Paré; Rémi Goupil; Catherine Fortier; Martin G. Schultz; James E. Sharman; Mohsen Agharazii

doi:10.2991/artres.k.201209.070

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Volume 26, Issue Supplement 1, December 2020, Pages S84 - S84

P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis

Authors

Nadège Côté¹^{, 2}^{, *}, Emy Philibert¹^{, 2}, Mathilde Paré¹^{, 2}, Rémi Goupil³, Catherine Fortier¹^{, 2}^{, 4}, Martin G. Schultz⁵, James E. Sharman⁵, Mohsen Agharazii¹^{, 2}

¹Division of Nephrology, Faculty of Medicine, Université Laval

²CHU de Québec Research Center, L’Hôtel-Dieu de Québec Hospital

³Hôpital du Sacré-Cœur de Montréal

⁴INSERM U-970, Paris Cardiovascular research Center (PARCC)

⁵Menzies Institute for Medical Research, University of Tasmania

^*Corresponding author. Email: nadege.cote.1@ulaval.ca

Corresponding Author

Nadège Côté

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.070 How to use a DOI?
Keywords: Kidney transplantation; reservoir-wave analysis
Abstract: Purpose/Background/Objective: According to reservoir-wave approach (RWA) arterial pressure is the sum of a reservoir pressure (RP) accounting for dynamic storage and release of blood from arteries, and an excess pressure (XSP) analogous to flow. RP is the minimal left ventricular work required to generate aortic flow, while XSP corresponds to surplus cardiac workload. We have previously shown that kidney transplantation (KTx) improves aortic stiffness [1], however, by adding renal vessels to existing vascular network, KTx may increase cardiac output. Thus, we aimed to examine whether XSP increases after KTx.

Methods: Before and 3 months after KTx, carotid pressure waves were recorded using arterial tonometry, calibrated using brachial diastolic and mean blood pressure. Using pressure only approach, reservoir-wave analysis was used to derive RP, XSP and their integrals (RPI, XSPI). RWA parameters were compared with Wilcoxon non-parametric test using SPSS 26.0.

Results: 75 patients (69% male, mean age 51 ± 13 years) were assessed. Three months after KTx, both carotid RP (121.2 ± 20.7 vs 103.5 ± 15.7, p < 0.001) and RPI (11192.52 ± 2763.11 vs 9531 ± 1978, p < 0.001) decreased significantly, but carotid XSP and XSPI remained unchanged. Carotid systolic (131.0 ± 23.2 vs 114.1 ± 15.5, p < 0.001) and diastolic (83.4 ± 11.9 vs 72.8 ± 9.93, p < 0.001) blood pressures were also reduced.

Conclusion: KTx decreased reservoir pressure, suggesting a decrease in minimal cardiac workload. However, we did not see an increase in excess pressure or its integral, suggesting that addition of a donor renal artery does not significantly alter cardiac outflow and excess workload 3 months after KTx.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S84 - S84
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.070 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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ris enw bib

TY  - JOUR
AU  - Nadège Côté
AU  - Emy Philibert
AU  - Mathilde Paré
AU  - Rémi Goupil
AU  - Catherine Fortier
AU  - Martin G. Schultz
AU  - James E. Sharman
AU  - Mohsen Agharazii
PY  - 2020
DA  - 2020/12/31
TI  - P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis
JO  - Artery Research
SP  - S84
EP  - S84
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.070
DO  - 10.2991/artres.k.201209.070
ID  - Côté2020
ER  -

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