P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound

Kiran V Raj; P M Nabeel; Jayaraj Joseph; Dinu Chandran; Mohanasankar Sivaprakasam

doi:10.2991/artres.k.201209.053

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Volume 26, Issue Supplement 1, December 2020, Pages S63 - S63

P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound

Authors

Kiran V Raj¹, P M Nabeel², Jayaraj Joseph¹^{, 2}^{, *}, Dinu Chandran³, Mohanasankar Sivaprakasam¹^{, 2}

¹Department of Electrical Engineering, Indian Institute of Technology Madras

²Healthcare Technology Innovation Centre, Indian Institute of Technology Madras

³Department of Physiology, All India Institute of Medical Sciences

^*Corresponding author. Email: jayaraj@ee.iitm.ac.in

Corresponding Author

Jayaraj Joseph

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.053 How to use a DOI?
Keywords: Fast-ultrasound; incremental-PWV; image-free ultrasound
Abstract: Background: The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light [1]. While reported methods require arterial pressure and diameter measurements from a single site to assess intra-beat changes in C, we present an image-free fast ultrasound device that performs this by capturing diameter waveforms from two proximal locations on an artery._.

Methods: The functionality was assessed on eight normotensive participants (26 ± 4 years). By perturbing blood pressure through a short duration moderate lower body negative pressure intervention [2], C_D and C_F pulse wave velocities corresponding to diastolic and 80% of peak pressure were measured from the carotid artery. Human NIBP system (ADInstruments, India) was used for monitoring continuous pressure.

Results: The device captured dual-diameter waveforms and evaluated C_D and C_F, with a beat-to-beat variation <8% during baseline. C_D was smaller than C_F (p < 0.001), 4.2 ± 0.5 m/s versus 4.6 ± 0.7 m/s during baseline and 3.7 ± 0.6 m/s versus 3.9 ± 0.7 m/s during intervention. Concomitant to the drop in group-average diastolic (17%) and systolic (18%) pressures during the intervention, C_D and C_F dropped by 14% and 16%, respectively. The statistically significant correlation (r > 0.6, p < 0.001) of C_D and C_F with the diastolic and systolic pressures for each individual was preserved even after adjusting for heart-rate.

Conclusions: The device demonstrated its functionality and reliably measured the incremental nature of C. Its pressure-dependent intra-beat variations and inter-beat dynamics during the intervention concurred with literature. Further studies are underway to demonstrate the potential use of the device in vascular research and clinical applications.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S63 - S63
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.053 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Kiran V Raj
AU  - P M Nabeel
AU  - Jayaraj Joseph
AU  - Dinu Chandran
AU  - Mohanasankar Sivaprakasam
PY  - 2020
DA  - 2020/12/31
TI  - P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound
JO  - Artery Research
SP  - S63
EP  - S63
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.053
DO  - 10.2991/artres.k.201209.053
ID  - Raj2020
ER  -

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