P.04 A Transfer-Function-Free Technique for the Non-Invasive Estimation of Central Arterial Pressure

DOI

10.2991/artres.k.201209.018How to use a DOI?

Keywords

Non-invasive pressure estimation

Abstract

Background: Central aortic pressure (CAP) is important for the determination of the cardiovascular risk. Transfer function (TF)-based techniques allow for estimating CAP non-invasively from pressure waveforms acquired distally in the circulation. However, TF-based CAP might preserve the high frequencies of the distal waveform [1]. Therefore, we propose a new method where CAP is estimated from local direct non-invasive measurements of diameter (D) and blood velocity (U) waveforms.

Methods: Aortic root D and U were measured using an ultrasound scanner (GE, Vivid E95) in 10 healthy volunteers (46 ± 15 years, 5 men), and used to determine local wave speed (PWV) using the lnDU-loop method [2]. Brachial systolic (P_s) and diastolic blood pressure (P_d), as well as central P_s, were also estimated using a sphygmomanometer (Uscom, BPPLUS-R7). CAP was determined as:

, where, and blood density = 1060 kg/m³.

Results: Mean brachial P_s and P_d were 124.1 ± 9.5 and 77.9 ± 5.4 mmHg, respectively. Mean PWV was 3.07 ± 0.71 m/s, leading to = 1.00 ± 0.46. The average calculated P_s was only –0.4% lower than TF-P_s (116.4 ± 11.2 vs. 116.9 ± 8.9, mmHg). Estimated calculated aortic and measured brachial mean pressure were almost identical with a difference of 0.01% (97.8 ± 6.9 vs. 97.8 ± 6.5, mmHg).

Discussion: This proof-of-concept study shows that the CAP waveform can be estimated non-invasively from measurements of brachial P_d, and aortic D and U obtained using equipment available in almost every cardiovascular clinic. Further studies are warranted to establish the full utility of the new technique.

Figure

A: typical example of aortic D converted into CAP. B: Bland-Altman comparison between calculated and TF P_s.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Alessandro Giudici
AU  - Ioana Cretu
AU  - Madalina Negoita
AU  - Ian B Wilkinson
AU  - Ashraf W Khir
PY  - 2020
DA  - 2020/12/31
TI  - P.04 A Transfer-Function-Free Technique for the Non-Invasive Estimation of Central Arterial Pressure
JO  - Artery Research
SP  - S24
EP  - S24
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.018
DO  - 10.2991/artres.k.201209.018
ID  - Giudici2020
ER  -