Effect of Body Habitus and Heart Rate on Accuracy of Aortic-Radial Transfer Functions for Predicting Central Hemodynamic Indices in Growing Children

Authors

Tommy Y. Cai^{1, 2, 3}, Ahmad Qasem⁴, Mark Butlin^4, , Alberto Avolio^4, , Julian G. Ayer^{1, 5}, David S. Celermajer^{1, 3}, Michael R. Skilton^{1, 2, *,}

¹Sydney Medical School, The University of Sydney, Sydney, NSW, Australia

²Boden Collaboration for Obesity, Nutrition, Exercise and Eating, The University of Sydney, Sydney, NSW, Australia

³Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia

⁴Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia

⁵Heart Centre for Children, The Children’s Hospital at Westmead, Sydney, NSW, Australia

^*Corresponding author. Email: michael.skilton@sydney.edu.au

DOI

10.2991/artres.k.201003.001How to use a DOI?

Keywords

Central blood pressure; central arterial hemodynamics; transfer functions; paediatrics

Abstract

Central Systolic Blood Pressure (cSBP) and Central Augmentation Index (cAIx) have been independently associated with cardiovascular risk in adults, and can be estimated using a generalized peripheral-to-central transfer function. We hypothesize that transfer function accuracy and precision will be influenced by degree of growth and change in body habitus during periods of growth, such as in childhood. We studied the pulse pressure waveforms of 91 healthy children at 8-years of age, and subsequently at 14-years of age. Waveforms were obtained by high-fidelity applanation tonometry of the radial and carotid arteries. Individualized radial-to-carotid transfer functions were formulated at 8-years of age and applied at 14-years of age to estimate cSBP and cAIx. Accuracy was defined as the difference between directly measured and predicted values, and precision as the residuals. Changes in weight (vs. error: β = −0.22, p = 0.04; vs. residuals: β = 0.30; p < 0.01) and body mass index (vs. residuals: β = 0.28, p < 0.01), between 8 and 14 years of age were associated with accuracy and precision of individualized transfer functions in predicting cSBP at 14 years of age. Change in weight (vs. residuals: β = 0.30; p < 0.01) and heart rate (vs. residuals β = 0.32, p < 0.01) were associated with the precision in predicting cAIx. Changes in body habitus and heart rate over a 6-year period of growth are associated with the predictive accuracy and precision of individualized transfer functions in children suggestive of changes in the frequency response characteristics of an individual’s vascular system during growth periods.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Tommy Y. Cai
AU  - Ahmad Qasem
AU  - Mark Butlin
AU  - Alberto Avolio
AU  - Julian G. Ayer
AU  - David S. Celermajer
AU  - Michael R. Skilton
PY  - 2020
DA  - 2020/10/12
TI  - Effect of Body Habitus and Heart Rate on Accuracy of Aortic-Radial Transfer Functions for Predicting Central Hemodynamic Indices in Growing Children
JO  - Artery Research
SP  - 242
EP  - 249
VL  - 26
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201003.001
DO  - 10.2991/artres.k.201003.001
ID  - Cai2020
ER  -