5.1 VULNERABLE CAROTID PLAQUES ARE ASSOCIATED WITH THE DEVELOPMENT OF EARLY RESTENOSIS AFTER CAROTID ENDARTERECTOMY

DOI

10.1016/j.artres.2013.10.024How to use a DOI?

Abstract

Background. Carotid endarterectomy (CEA) is widely recognised as an effective surgical method in both symptomatic and asymptomatic patients with significant internal carotid artery stenosis. Although the association between vulnerable carotid plaques and stroke is well established, little is known about their role in development of myointimal hyperplasia after carotid surgery. In the current study we aimed to establish correlation between plaque morphology (as observed by ultrasonic scan) and the degree of myointimal hyperplasia after CEA.

Methods. A total of 567 patients with a median age of 65.0 ± 5,6 years who underwent CEA were examined using duplex ultrasound scanning prior to surgery and 12 months after. The morphology of plaques in terms of their echogenicity was graded as echolucent, predominantly echolucent, predominantly echogenic, echogenic, or calcified. The plaque surface was categorized as smooth, irregular, or ulcerated. Chi-square test and multivariate logistic regression were used for statistical analysis.

Results. Internal carotid artery restenosis due to intimal hyperplasia ≥50% were detected in 67 patients (11,82%). The incidence of carotid restenosis was significantly higher in patients with ulcerated carotid plaques (P < 0.05). There was no difference between rates of restenosis in patients who had plaques with smooth or irregular surface. Predominantly echolucent carotid plaque appeared to be an independent predictor of carotid restenosis in 12 months after CEA (P < 0.05).

Conclusion. The results of our study suggest that vulnerable carotid plaques can lead to myointimal hyperplasia after CEA and can be considered as an independent predictor of early restenosis after carotid surgery.

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TY  - JOUR
AU  - E.A. Surkova
AU  - O.V. Tereshina
AU  - A.N. Vachev
PY  - 2013
DA  - 2013/11/11
TI  - 5.1 VULNERABLE CAROTID PLAQUES ARE ASSOCIATED WITH THE DEVELOPMENT OF EARLY RESTENOSIS AFTER CAROTID ENDARTERECTOMY
JO  - Artery Research
SP  - 168
EP  - 168
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.024
DO  - 10.1016/j.artres.2013.10.024
ID  - Surkova2013
ER  -