2.4 SERUM BIOMARKERS AND RETINAL VESSEL DIAMETERS IN SCHOOL CHILDREN

H. Hanssen; M. Siegrist; M. Neidig; C. Lammel; B. Haller; K.G. Parhofer; M. Vogeser; M. Halle

doi:10.1016/j.artres.2013.10.010

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Volume 7, Issue 3-4, September 2013, Pages 163 - 164

2.4 SERUM BIOMARKERS AND RETINAL VESSEL DIAMETERS IN SCHOOL CHILDREN

Authors

H. Hanssen¹, M. Siegrist², M. Neidig², C. Lammel², B. Haller³, K.G. Parhofer⁴, M. Vogeser⁵, M. Halle²

¹Division of Sports- and Exercise Medicine, Institute of Exercise and Health Sciences, University of Basel, Basel, Switzerland

²Department of Prevention and Sports Medicine, Technische Universitaet Muenchen, Munich, Germany

³Institute of Medical Statistics and Epidemiology, Technische Universitaet Muenchen, Munich, Germany

⁴Department of Internal Medicine II, University of Munich, Grosshadern Campus, Munich, Germany

⁵Department of Clinical Chemistry, University of Munich, Grosshadern Campus, Munich, Germany

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.010 How to use a DOI?
Abstract: Objectives. Retinal vessel analysis is a valid diagnostic tool to detect subclinical signs of atherosclerosis in the cerebrovascular microcirculation as early as childhood. The aim of the study was to investigate the association between specific obesity-related biomarkers and retinal vessel diameters in school children.

Methods. We studied 381 children aged 10 to 13 years in a school-based setting. Anthropometric measurements and blood sampling were conducted using standard protocols for children. The serum biomarkers leptin, insulin, adiponectin and IL-6 were assessed and correlated with retinal arteriolar (CRAE) and venular (CRVE) diameters and the arteriolar-to- venular ratio (AVR). Retinal vessel analysis was performed by use of a non-mydriatic vessel analyser (SVA-T) using a computer-based program.

Results. Overweight and obese children had higher leptin and insulin levels and reduced adiponectin levels compared to normal weight children (p < 0.05). IL-6-levels were significantly higher in obese children compared to normal weight peers (p < 0.001). Wider CRVE (p = 0.031) and lower AVR (P = 0.01) were associated with higher leptin levels. Insulin levels were associated with arteriolar as well as venular dilatation depending on confounder adjustment.

Conclusions. All of the above serum risk factors are altered in childhood obesity. However, only leptin and insulin levels are associated with retinal vessel diameter changes, a cumulative microvascular biomarker. Intervention studies are warranted to examine whether lifestyle improvements can prevent alterations of the vasculature early in life.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 163 - 164
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.010 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - H. Hanssen
AU  - M. Siegrist
AU  - M. Neidig
AU  - C. Lammel
AU  - B. Haller
AU  - K.G. Parhofer
AU  - M. Vogeser
AU  - M. Halle
PY  - 2013
DA  - 2013/11/11
TI  - 2.4 SERUM BIOMARKERS AND RETINAL VESSEL DIAMETERS IN SCHOOL CHILDREN
JO  - Artery Research
SP  - 163
EP  - 164
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.010
DO  - 10.1016/j.artres.2013.10.010
ID  - Hanssen2013
ER  -

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